{"id":"W4313439076","doi":"10.1038/s41581-022-00662-0","title":"Gasdermins and pyroptosis in the kidney","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Nephrology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Pyroptosis; Inflammasome; Programmed cell death; Cell biology; Secretion; Caspase 1; Effector; Medicine; Apoptosis; Biology; Immunology; Inflammation; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008853936,0.0004585033,0.001396277,0.0001549306,0.00007358448,0.00002496991,0.00060588,0.001625723,0.00001650057],"category_scores_gemma":[0.0005398255,0.0002774952,0.0004744301,0.0004186686,0.0001331276,0.000002836081,0.0002150594,0.001164668,0.000131656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196087,"about_ca_system_score_gemma":0.0001758552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004939344,"about_ca_topic_score_gemma":0.00004942652,"domain_scores_codex":[0.997475,0.0007802938,0.0006577456,0.0005793067,0.00009734946,0.0004103086],"domain_scores_gemma":[0.9988247,0.00006908854,0.0002829935,0.0007407998,0.0000254292,0.00005701281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008490389,0.00002968652,0.000008951935,0.007839175,0.0001342487,0.00001883384,0.00004202503,3.430462e-8,0.00004324916,0.0002218762,0.08262901,0.9090244],"study_design_scores_gemma":[0.0001537683,0.00008944047,0.00001195016,0.001412774,0.0002718302,0.0001081641,0.00001038751,1.915492e-7,0.000002175003,0.00003788363,0.9976309,0.0002705222],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002347513,0.9972501,0.000001947166,0.0003829241,0.0002249441,0.001306842,0.00002465784,0.00001034505,0.0007747092],"genre_scores_gemma":[0.000003803241,0.9920799,0.00003138714,0.005988732,0.0003355188,0.0004377661,0.0006897422,0.00005596924,0.0003771532],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9150019,"threshold_uncertainty_score":0.9999677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794038829559604,"score_gpt":0.3460183516519287,"score_spread":0.3180779633563327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}