{"id":"W4313446348","doi":"10.1007/978-1-0716-2914-7_8","title":"Assessing the Immune Regulatory Role of Metabolites In Vitro","year":2023,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of Ottawa; University of British Columbia; University of Victoria","funders":"","keywords":"Immune system; Metabolite; Tumor microenvironment; In vitro; Biology; In vitro toxicology; Cell; Regulatory T cell; Cell type; Computational biology; T cell; Cell biology; Immunology; Biochemistry; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008565934,0.0006864916,0.0003848222,0.0004248949,0.0002458116,0.0005798278,0.0003612197,0.0005016489,0.002187607],"category_scores_gemma":[0.0005449187,0.0002139577,0.0003771535,0.0003540443,0.0003598377,0.0003973205,0.0003210565,0.000950784,0.0007765346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314347,"about_ca_system_score_gemma":0.0003112885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004831142,"about_ca_topic_score_gemma":0.001039682,"domain_scores_codex":[0.999329,0.0002968858,0.00003503253,0.0001168557,0.0001186305,0.0001036515],"domain_scores_gemma":[0.9991729,0.0004781039,0.0000686741,0.00009395045,0.0001160162,0.00007035644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004544883,0.0001001264,0.0002847128,0.00003512512,0.00000622989,0.00002432872,0.00001318513,0.00008698917,0.9975414,0.00005744574,0.0000246388,0.001371354],"study_design_scores_gemma":[0.00001847421,0.0007839833,0.001520833,0.000004084454,0.00001954092,0.000037155,0.00001452745,0.0003100119,0.9965088,0.00005249273,0.0007267052,0.000003445666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9446161,0.00824082,0.03543314,0.000223157,0.0002784006,0.0002941803,0.001421583,0.0002435498,0.0092491],"genre_scores_gemma":[0.9666066,0.003198788,0.02171321,0.0001974116,0.0001249768,0.0002370976,0.001988438,0.00007809758,0.005855372],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002187607,"threshold_uncertainty_score":0.007318258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917065026674262,"score_gpt":0.3678071631167047,"score_spread":0.3486365128499621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}