{"id":"W4313451663","doi":"10.1002/ange.202214539","title":"A Type 1 Aldolase, NahE, Catalyzes a Stereoselective Nitro‐Michael Reaction: Synthesis of β‐Aryl‐γ‐nitrobutyric Acids","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Stereoselectivity; Michael reaction; Decarboxylation; Aryl; Aldolase A; Catalysis; Substrate (aquarium); Nitro; Yield (engineering); Organic chemistry; Combinatorial chemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840741,0.0002083252,0.0003253512,0.00007607356,0.0001579024,0.0000126259,0.0002880167,0.0001019259,0.0002654174],"category_scores_gemma":[0.0002196254,0.0002061766,0.0002492682,0.0004466562,0.00008216234,0.000007078289,0.000267742,0.0001608098,0.000007773637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000630804,"about_ca_system_score_gemma":0.00008373085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001469326,"about_ca_topic_score_gemma":0.00002357345,"domain_scores_codex":[0.9987192,0.00003372191,0.0002795201,0.0004426776,0.0002519647,0.000272875],"domain_scores_gemma":[0.9991122,0.0000642698,0.0001773813,0.0004240901,0.0001302006,0.00009178812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002090251,0.0001663912,0.001652872,0.00002540747,0.0002838484,0.000003301051,0.00005280674,0.000005894809,0.9932835,0.000006046526,0.003562245,0.0007487045],"study_design_scores_gemma":[0.0002259222,0.0001255125,0.0003417726,0.0000104963,0.0001575963,0.00001954905,0.0002688848,0.000005221751,0.9691838,0.00004496078,0.02938293,0.0002333724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944643,0.001386087,0.00001704564,0.0001619422,0.00006896451,0.0001026261,0.0001428149,0.00002069644,0.003635508],"genre_scores_gemma":[0.9980565,0.0002283112,0.0001616085,0.0001457933,0.0001801044,0.00009401383,0.0002766054,0.00003305203,0.0008240225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02582069,"threshold_uncertainty_score":0.8407637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003315348476716,"score_gpt":0.2266142041424062,"score_spread":0.2165810506576391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}