{"id":"W4313453633","doi":"10.1038/s41594-022-00861-0","title":"In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes","year":2023,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Goddard Space Flight Center; Helen Hay Whitney Foundation; Howard Hughes Medical Institute; National Science Foundation; National Institutes of Health; University of California, San Francisco; Echo Foundation","keywords":"Cryo-electron tomography; Flagellum; Sperm; Microtubule; Cell biology; Axoneme; Dynein; Electron tomography; Biology; Sea urchin; Biophysics; Anatomy; Electron microscope; Genetics; Tomography; Physics; Optics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298958,0.0002988907,0.0003294752,0.0003921822,0.00007082178,0.00001386795,0.0005815057,0.0007994929,0.00001101026],"category_scores_gemma":[0.0001642841,0.0002141387,0.0002748154,0.001222856,0.0002108659,0.000003715808,0.0002199444,0.0006710399,0.000004177717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001607758,"about_ca_system_score_gemma":0.0000508005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004769845,"about_ca_topic_score_gemma":0.0002358588,"domain_scores_codex":[0.9981567,0.0002354772,0.000349783,0.0005516848,0.0001416606,0.0005647038],"domain_scores_gemma":[0.9991152,0.00002788744,0.0001325717,0.000570241,0.00009079065,0.000063317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007885668,0.000009016444,0.002235665,0.00002608691,0.00008461693,0.00001620374,0.00004039053,0.00007755588,0.9910123,0.00373559,0.0008576184,0.001826123],"study_design_scores_gemma":[0.0006327091,0.000392031,0.021942,0.00001418534,0.00003653267,0.00007942731,0.00004301174,0.00001924687,0.9573609,0.007090858,0.01203123,0.0003578713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927106,0.004302929,0.0002436729,0.001448627,0.0003534283,0.0003975536,0.00006163328,0.00002136994,0.0004601393],"genre_scores_gemma":[0.9971835,0.0001960055,0.0004075909,0.001335663,0.0001888588,0.00002177877,0.0004758376,0.0000328697,0.0001578646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03365139,"threshold_uncertainty_score":0.8732322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003029163478900357,"score_gpt":0.2665455706751249,"score_spread":0.2635164071962245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}