{"id":"W4313453663","doi":"10.1002/ajh.26809","title":"Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study","year":2023,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Microsemi (Canada); McGill University; Jewish General Hospital","funders":"","keywords":"Venetoclax; Medicine; Lymphoma; Brentuximab vedotin; Obinutuzumab; Follicular lymphoma; Rituximab; Oncology; Internal medicine; Antibody-drug conjugate; Cancer research; Antibody; Immunology; Chronic lymphocytic leukemia; Leukemia; Monoclonal antibody; CD30","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002707796,0.0002276993,0.001104112,0.0002111622,0.00006373045,0.00002054824,0.00005108116,0.00005178337,0.000001905714],"category_scores_gemma":[0.0001285253,0.0001529502,0.0000468744,0.0002478581,0.0002809589,0.0000913055,0.00004731076,0.00009597011,0.000001005633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134825,"about_ca_system_score_gemma":0.0002328792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007984865,"about_ca_topic_score_gemma":0.0003326909,"domain_scores_codex":[0.9982749,0.0001714805,0.0007043878,0.0003816121,0.0001904758,0.0002771678],"domain_scores_gemma":[0.9980942,0.0009829312,0.0004583203,0.0001872319,0.00005737606,0.0002199335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02129634,0.003924951,0.890343,0.00004969128,0.001353218,0.009753183,0.01536211,0.00009510329,0.000175394,0.0001373855,0.000295463,0.05721413],"study_design_scores_gemma":[0.1159272,0.02986194,0.8314572,0.0008043074,0.0008784275,0.002133474,0.01388345,0.00313644,0.0002947505,0.0008420803,0.0003818496,0.00039892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943776,0.003940978,0.00001473286,0.001161556,0.00003410307,0.0003874247,0.00002651082,0.00001364789,0.00004343301],"genre_scores_gemma":[0.9955731,0.002055249,0.002168304,0.00008841596,0.000041061,0.00002525133,0.00001046778,0.00002088321,0.0000172912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09463082,"threshold_uncertainty_score":0.6237127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619885197197588,"score_gpt":0.3340474590618898,"score_spread":0.3078486070899139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}