{"id":"W4313454001","doi":"10.1021/acs.analchem.2c03751","title":"Are We There Yet? Intracellular Sensing with Luminescent Nanoparticles and FRET","year":2023,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; University of British Columbia; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Förster resonance energy transfer; Chemistry; Nanotechnology; Energy transfer; Luminescence; Nanoparticle; Bottleneck; Intracellular; Fluorescence; Optoelectronics; Computer science; Chemical physics; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006153009,0.0007061831,0.001362998,0.0008095333,0.001248346,0.004684241,0.001241235,0.003213505,0.004232022],"category_scores_gemma":[0.006330049,0.000495174,0.0006672856,0.00075678,0.003272517,0.01308312,0.002037288,0.00704483,0.00303049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001560403,"about_ca_system_score_gemma":0.001874879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118409,"about_ca_topic_score_gemma":0.001841722,"domain_scores_codex":[0.998688,0.0004621847,0.0001012965,0.0002229102,0.000333689,0.0001918647],"domain_scores_gemma":[0.9973637,0.00159293,0.0001976941,0.0001215711,0.0005036005,0.0002203726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003796706,0.0001938467,0.002505442,0.006085707,0.0002241482,0.0009167427,0.002126194,0.0006114355,0.02775442,0.1980241,0.1186059,0.6425723],"study_design_scores_gemma":[0.00002507125,0.0002004005,0.0007420545,0.003033353,0.0001140848,0.001373705,0.003933506,0.0007378318,0.01819809,0.1499298,0.8215641,0.0001480657],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.005909335,0.7254449,0.03008719,0.2158861,0.00998256,0.00004803245,0.0002464681,0.0003469214,0.01204862],"genre_scores_gemma":[0.08475249,0.7582603,0.04241247,0.08795117,0.006902188,0.0002575197,0.0003973071,0.0002279153,0.01883866],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006153009,"threshold_uncertainty_score":0.03254056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395795190141816,"score_gpt":0.258881238708445,"score_spread":0.2449232868070268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}