{"id":"W4313458715","doi":"10.1085/jgp.202213224","title":"Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD","year":2023,"lang":"en","type":"letter","venue":"The Journal of General Physiology","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Vetenskapsrådet","keywords":"ORAI1; Skeletal muscle; Computational biology; Medicine; Bioinformatics; Pharmacology; Biology; Internal medicine; Voltage-dependent calcium channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001534652,0.0005072724,0.001257842,0.0002930617,0.001039657,0.001143354,0.0009289326,0.01675452,0.004114335],"category_scores_gemma":[0.005396141,0.0003064832,0.0008477261,0.000213655,0.001596735,0.00175841,0.000632058,0.01983098,0.00371688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001584111,"about_ca_system_score_gemma":0.001361881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000992364,"about_ca_topic_score_gemma":0.002759137,"domain_scores_codex":[0.9993194,0.0001921679,0.0001009838,0.00008523958,0.0002205433,0.00008162073],"domain_scores_gemma":[0.997915,0.00120037,0.0001311019,0.00006233212,0.0003674905,0.0003237128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004220926,0.0001532045,0.0004793585,0.0001791538,0.00004250726,0.003234444,0.00006702712,0.0002020306,0.001709936,0.007499866,0.9321402,0.05387028],"study_design_scores_gemma":[0.000462971,0.0003972763,0.001189351,0.000241477,0.0000526488,0.002491112,0.000137536,0.0007588104,0.00100387,0.01941558,0.9737849,0.00006436324],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001244732,0.01001149,0.0003963609,0.9462934,0.03806816,0.00002183976,0.0001081672,0.00007166201,0.003784283],"genre_scores_gemma":[0.01288471,0.0142422,0.0009433318,0.8441438,0.1116266,0.00008605507,0.0001096363,0.00004651022,0.01591719],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01675452,"threshold_uncertainty_score":0.01376379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08956675902634213,"score_gpt":0.3356094566362612,"score_spread":0.2460426976099191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}