{"id":"W4313472141","doi":"10.3390/cancers15010272","title":"Current State of Immunotherapy and Mechanisms of Immune Evasion in Ewing Sarcoma and Osteosarcoma","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Government of Ontario; Technische Universität München; St. Baldrick's Foundation","keywords":"Osteosarcoma; Cancer research; Immunotherapy; Immune system; Sarcoma; Immunogenicity; Reprogramming; Tumor microenvironment; Antigen; Immunology; Medicine; Biology; Pathology; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006924407,0.0004112271,0.00191534,0.0004972409,0.0001120299,0.000008003195,0.0003268636,0.0001816378,0.0002626077],"category_scores_gemma":[0.00003955106,0.0003641077,0.0002882317,0.0003297934,0.0003526171,0.00007623264,0.0002068618,0.0006490357,0.000002545359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003804378,"about_ca_system_score_gemma":0.0006972513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003593966,"about_ca_topic_score_gemma":0.00001011433,"domain_scores_codex":[0.9972889,0.0008039844,0.00110225,0.0003866057,0.00006614756,0.0003521589],"domain_scores_gemma":[0.9982884,0.0004658838,0.0007808007,0.0004234127,0.00002767652,0.00001382975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004443509,0.00003440433,0.00000437416,0.003307984,0.0003385813,0.000002639666,0.0005420513,0.00000103063,0.01595073,0.000125895,0.000009611924,0.9792383],"study_design_scores_gemma":[0.002084498,0.0006543656,0.0001287374,0.00889923,0.0001586022,0.0001020993,0.0001555998,0.000001039426,0.006352338,0.000326759,0.9807095,0.0004272296],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007328198,0.9909753,0.00003700326,0.000004307024,0.0007406224,0.0007370982,0.0001360095,0.00001500714,0.0000264498],"genre_scores_gemma":[0.002789932,0.9967797,0.00002536752,0.00001038891,0.000004625301,0.0001121627,0.0001003114,0.00005447984,0.0001230061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9806999,"threshold_uncertainty_score":0.9998811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03273511373085971,"score_gpt":0.3045566572377134,"score_spread":0.2718215435068537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}