{"id":"W4313472141","doi":"10.3390/cancers15010272","title":"Current State of Immunotherapy and Mechanisms of Immune Evasion in Ewing Sarcoma and Osteosarcoma","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Government of Ontario; Technische Universität München; St. Baldrick's Foundation","keywords":"Osteosarcoma; Cancer research; Immunotherapy; Immune system; Sarcoma; Immunogenicity; Reprogramming; Tumor microenvironment; Antigen; Immunology; Medicine; Biology; Pathology; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008916278,0.0007607859,0.001210949,0.001649527,0.0002880407,0.001134245,0.0008879784,0.001530043,0.001683514],"category_scores_gemma":[0.0008270177,0.0003251756,0.0004106547,0.001489874,0.0008145273,0.002228786,0.0008558505,0.002549321,0.001197803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006622671,"about_ca_system_score_gemma":0.0009144673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005702282,"about_ca_topic_score_gemma":0.0009040818,"domain_scores_codex":[0.9997823,0.00003997688,0.00003288208,0.00003479086,0.00008498467,0.00002507903],"domain_scores_gemma":[0.999674,0.0001750753,0.0000408711,0.00001110855,0.00006375601,0.00003528383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009423478,0.0000905138,0.0001453144,0.009719784,0.00004063918,0.0002288871,0.0000721125,0.0004937995,0.002306966,0.006724449,0.02836787,0.9517155],"study_design_scores_gemma":[0.00002080245,0.0001084067,0.0005328468,0.002685535,0.00004141712,0.001209717,0.00006350251,0.0001145996,0.0005049671,0.00436797,0.9903345,0.00001590281],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005983926,0.9989723,0.00007555624,0.0002933176,0.0002185617,0.000001668574,0.000003065601,0.000004029848,0.0003716443],"genre_scores_gemma":[0.0004982317,0.9982994,0.0001168032,0.0003051395,0.0004143014,0.000005250375,0.00001037424,0.000001148209,0.0003493868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001683514,"threshold_uncertainty_score":0.005631864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03273511373085971,"score_gpt":0.3045566572377134,"score_spread":0.2718215435068537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}