{"id":"W4313472389","doi":"10.3390/v15010123","title":"Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in Mice","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense; Defense Health Agency; U.S. Department of Defense","keywords":"Polyclonal antibodies; Pharmacodynamics; Pharmacokinetics; Pharmacology; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Medicine; Virology; 2019-20 coronavirus outbreak; Immunology; Internal medicine; Infectious disease (medical specialty); Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875866,0.0005040176,0.0005234468,0.0003711386,0.0001337947,0.0003914004,0.0002521639,0.0004252254,0.0007570876],"category_scores_gemma":[0.0002443803,0.0002767763,0.0003732273,0.0001890066,0.0002674887,0.00045807,0.0000954434,0.00130539,0.0003906815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004847858,"about_ca_system_score_gemma":0.0003444435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009299124,"about_ca_topic_score_gemma":0.0008414312,"domain_scores_codex":[0.9997987,0.00003705066,0.000009171469,0.00004740664,0.00004020266,0.00006754267],"domain_scores_gemma":[0.9997901,0.0000338759,0.00007608983,0.00001895118,0.00001900175,0.00006205002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002926207,0.0005157268,0.000631979,0.00003438487,0.00002095862,0.00004444016,0.00003552143,0.0005966019,0.9894305,0.00008152318,0.0002675651,0.005414451],"study_design_scores_gemma":[0.0004168525,0.02056016,0.01354019,0.00001201449,0.0001546644,0.000391802,0.00006256992,0.007007461,0.9533798,0.0001994355,0.004236239,0.00003884613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938048,0.001269143,0.002369147,0.000177994,0.00004300616,0.00004411319,0.0008614876,0.0002106675,0.001219674],"genre_scores_gemma":[0.9921091,0.001200531,0.001767923,0.0001821893,0.00004831059,0.00009021159,0.001206351,0.00009564742,0.003299871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009299124,"threshold_uncertainty_score":0.00351733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912192413741058,"score_gpt":0.3597129640764388,"score_spread":0.3305910399390282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}