{"id":"W4313480728","doi":"10.1016/j.ejpb.2022.12.017","title":"Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo","year":2023,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eisai Canada","keywords":"Mannose receptor; Mannose; Oligonucleotide; Gene silencing; In vivo; Molecular biology; In vitro; Chemistry; Gene expression; Pancreas; Biology; Biochemistry; Cell biology; Macrophage; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002907781,0.0004848997,0.0004352572,0.0002563041,0.0001885923,0.000390212,0.0002447872,0.0005779171,0.0009751264],"category_scores_gemma":[0.0001042342,0.0002426651,0.0003214657,0.0001655724,0.0003360602,0.000226768,0.0002861559,0.0009305355,0.0004439468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681112,"about_ca_system_score_gemma":0.0003259715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007516473,"about_ca_topic_score_gemma":0.0008981888,"domain_scores_codex":[0.9997371,0.0000342487,0.00002344914,0.00005944506,0.00006224419,0.00008353114],"domain_scores_gemma":[0.9998556,0.00002793747,0.00003828919,0.00002324795,0.00001863774,0.00003632678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009530229,0.00001236185,0.0000235146,0.00001281075,0.00000295481,0.00001745758,0.000007097298,0.0000194077,0.9994571,0.00004649915,0.00001401198,0.0002914379],"study_design_scores_gemma":[0.00001376256,0.0001417443,0.0004062036,0.000001655865,0.00001129958,0.00004924037,0.0000100939,0.000223905,0.9986151,0.00002070091,0.000504075,0.000002096318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903607,0.001245253,0.005686926,0.0001660281,0.00006338573,0.0000401616,0.0002649849,0.0001937472,0.00197879],"genre_scores_gemma":[0.9919847,0.0006087499,0.002574325,0.00009852367,0.00001609102,0.00005513753,0.0002735407,0.00005242813,0.004336452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009751264,"threshold_uncertainty_score":0.003262162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04869499902366738,"score_gpt":0.3090673573180976,"score_spread":0.2603723582944303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}