{"id":"W4313488074","doi":"10.1158/2159-8290.cd-22-0786","title":"Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; University College London Hospitals NHS Foundation Trust; National Fusion Research Institute; Rosetrees Trust; Making Headway Foundation; Sarcoma UK; National Institutes of Health; Cancer Research UK; Boston Children's Hospital; Ira Sohn Research Conference Foundation","keywords":"Biology; Malignant peripheral nerve sheath tumor; CDKN2A; Genome instability; Exome sequencing; Chromosome instability; Cancer research; Comparative genomic hybridization; Neurofibromatosis; Exome; DNA methylation; Genetics; Phenotype; Genome; Chromosome; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323982,0.00009437178,0.0001003046,0.0004938897,0.00009639244,0.0001945573,0.00009891183,0.0002060389,0.00135644],"category_scores_gemma":[0.0008319755,0.00006475885,0.00006974063,0.0003979501,0.0001692464,0.0001514649,0.0001672912,0.0001671227,0.0001951392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089553,"about_ca_system_score_gemma":0.00006295106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004195679,"about_ca_topic_score_gemma":0.000617193,"domain_scores_codex":[0.9999113,0.00001327831,0.00000784776,0.00003472389,0.00001879888,0.00001392928],"domain_scores_gemma":[0.9994814,0.0001072823,0.0002632654,0.00003117814,0.00004029625,0.00007658824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005458747,0.00002294128,0.949449,0.00002642011,0.00004182616,0.000200905,0.00004491393,0.00009872122,0.03932174,0.00003994011,0.000124412,0.01008337],"study_design_scores_gemma":[0.000002220648,0.00006337895,0.9968933,0.000001825525,0.00001042245,0.0007236985,0.00002447359,0.0001318915,0.001950403,0.00004146666,0.0001551881,0.000001631295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988055,0.0003018908,0.0002106129,0.00001713529,0.000001810651,0.000004278014,0.0003580736,0.00001338374,0.0002873164],"genre_scores_gemma":[0.9991567,0.00008341835,0.0001940426,0.000009920596,0.000003418547,0.000004546955,0.0003278083,0.000002105676,0.0002181152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135644,"threshold_uncertainty_score":0.004537761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845260102874225,"score_gpt":0.2859152167475219,"score_spread":0.2574626157187797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}