{"id":"W4313493873","doi":"10.3390/curroncol30010051","title":"DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ontario Institute for Cancer Research","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Toxicity; Population; Exon; Copy-number variation; Medicine; Pharmacology; Biology; Oncology; Pharmacogenetics; Genetics; Cancer research; Internal medicine; Chemotherapy; Fluorouracil; Genotype; Gene; Thymidylate synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003180598,0.0003077718,0.001970452,0.0001190389,0.00005448766,0.000006127739,0.00006901494,0.0003003135,0.00005332053],"category_scores_gemma":[0.0002541848,0.0002275877,0.000177212,0.0004032221,0.0001269495,0.00003671868,0.00007868223,0.0003969993,0.00001771886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005049743,"about_ca_system_score_gemma":0.0004204981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001918868,"about_ca_topic_score_gemma":0.000188172,"domain_scores_codex":[0.9983565,0.000148035,0.0006052917,0.0004147893,0.0002304217,0.0002449262],"domain_scores_gemma":[0.9984859,0.0002896502,0.0006973256,0.0002187504,0.000221426,0.00008694774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000184925,0.0009194108,0.06802581,0.02388564,0.001710281,0.00009182269,0.0005703508,1.382772e-7,0.000004235759,0.0002112808,0.01167755,0.8927186],"study_design_scores_gemma":[0.002894825,0.00137438,0.0420117,0.01849316,0.006422962,0.0001721145,0.00005473621,0.00001738048,0.000004927706,0.00006505766,0.9280151,0.0004736333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006032829,0.9915504,0.00004181054,0.0001018967,0.000593427,0.0009352228,0.00006413183,0.0000770063,0.0006032115],"genre_scores_gemma":[0.002643117,0.9961544,0.00005851621,0.00002265601,0.0002823522,0.0001644701,0.0005124509,0.00004489771,0.0001171141],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9163376,"threshold_uncertainty_score":0.9280756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2180576160436588,"score_gpt":0.4475966773784462,"score_spread":0.2295390613347874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}