{"id":"W4313503211","doi":"10.3390/cancers15010025","title":"On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Helse Nord RHF; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Cancer Research Society; Kreftforeningen","keywords":"Triple-negative breast cancer; Cancer research; PI3K/AKT/mTOR pathway; Kinase; Breast cancer; Cell growth; Protein kinase B; Cancer; Mitogen-activated protein kinase; Medicine; Biology; Signal transduction; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005003318,0.0002220648,0.0002358318,0.0003438293,0.0001876582,0.0004269512,0.0002364341,0.0002993588,0.001422742],"category_scores_gemma":[0.0001666772,0.00006934234,0.0002698236,0.0002272179,0.0002726865,0.0003753935,0.0002081209,0.0007519564,0.0003171364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349422,"about_ca_system_score_gemma":0.0002605566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002049084,"about_ca_topic_score_gemma":0.0006408707,"domain_scores_codex":[0.9999076,0.00003257845,0.000006678919,0.000009098719,0.00002149105,0.00002253628],"domain_scores_gemma":[0.9999487,0.00001898524,0.000007793123,0.000005262576,0.00001049375,0.000008776135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005051577,0.001205775,0.001742521,0.001647896,0.0001286848,0.001206168,0.0002046743,0.001768019,0.6383181,0.01143533,0.004444582,0.3328468],"study_design_scores_gemma":[0.0009155666,0.01467438,0.01505824,0.000641575,0.0004477967,0.004588576,0.0005324344,0.003395945,0.6690066,0.008179682,0.2824967,0.00006254199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7072954,0.2453488,0.004208954,0.008315437,0.0007716293,0.0001236712,0.0003190009,0.0001128737,0.03350418],"genre_scores_gemma":[0.877931,0.1114854,0.002287786,0.001329185,0.0002768048,0.00007034258,0.0002232258,0.00002458913,0.006371624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422742,"threshold_uncertainty_score":0.00475949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092309516395087,"score_gpt":0.2387561471797045,"score_spread":0.2278330520157536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}