{"id":"W4313527876","doi":"10.1073/pnas.2208963120","title":"Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Scottish Rite Charitable Foundation of Canada; Government of Canada","keywords":"Neuroscience; Sensory system; Excitatory postsynaptic potential; Fragile X syndrome; Autism spectrum disorder; Glutamate receptor; Gene knockdown; Apical dendrite; Subthreshold conduction; Biology; Autism; Psychology; Physics; Cerebral cortex; Inhibitory postsynaptic potential; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367983,0.0005240988,0.0002773651,0.0005239063,0.0001649281,0.0002977898,0.0004379579,0.0006585669,0.001663001],"category_scores_gemma":[0.0001769745,0.0002992384,0.0004763703,0.0001596939,0.0003848972,0.0002953657,0.0003333477,0.0008544864,0.0002556274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004795854,"about_ca_system_score_gemma":0.0002382608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002035141,"about_ca_topic_score_gemma":0.002422444,"domain_scores_codex":[0.9998895,0.00001246263,0.00001583555,0.00003049211,0.00003013813,0.00002155811],"domain_scores_gemma":[0.9998287,0.0000258401,0.00007663816,0.00001210083,0.000009237123,0.00004749477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001400635,0.00003828576,0.0004091556,0.00003576267,0.00001410726,0.0003160012,0.00002359698,0.0009746551,0.9969344,0.0002708106,0.00003680708,0.0008062532],"study_design_scores_gemma":[0.0001705384,0.001139195,0.02320381,0.00006089078,0.0001537876,0.00159608,0.0001627368,0.0299877,0.9410968,0.0009290302,0.001460789,0.00003862916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955418,0.0001389915,0.003397297,0.00007724192,0.00001656719,0.00001218308,0.000319008,0.0001292722,0.0003677086],"genre_scores_gemma":[0.9938793,0.0002571299,0.004044963,0.00003729649,0.000003337118,0.00003868735,0.000204549,0.00004540145,0.001489344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002035141,"threshold_uncertainty_score":0.005563259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0462420322465022,"score_gpt":0.2895155262959775,"score_spread":0.2432734940494753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}