{"id":"W4313528637","doi":"10.1073/pnas.2204750120","title":"Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institutes of Health; Harvard T.H. Chan School of Public Health; National Institute of Diabetes and Digestive and Kidney Diseases; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute on Aging; Joslin Diabetes Center; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"AMPK; Dynamics (music); Physical fitness; Gerontology; Biology; Medicine; Psychology; Cell biology; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690256,0.0000773315,0.0001952029,0.0001053116,0.0001656944,0.0000151981,0.0002592753,0.0000488547,0.000003359105],"category_scores_gemma":[0.0003045748,0.00005068971,0.0000576835,0.0007237784,0.0005838199,0.0004228859,0.000176298,0.0001317586,0.000001381327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001322086,"about_ca_system_score_gemma":0.00001958409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007802983,"about_ca_topic_score_gemma":5.092014e-8,"domain_scores_codex":[0.9986847,0.000002511379,0.0001730498,0.0001989904,0.0007923124,0.0001484375],"domain_scores_gemma":[0.9996089,0.00006096844,0.0001542411,0.000007814003,0.0001326411,0.0000354362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047974,0.0001100928,0.01515335,0.0008043363,0.00005280496,1.13411e-7,0.003503237,0.00007445794,0.8994399,0.07798012,0.0009958463,0.001780978],"study_design_scores_gemma":[0.0008717578,0.00004496223,0.418058,0.0006621286,0.0001063239,0.00002315378,0.0008628904,0.00512318,0.5044073,0.06944157,0.0002641569,0.0001345876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944876,0.0002497768,3.325518e-7,0.003551569,0.00003344994,0.0001908386,0.000007834676,0.00002463867,0.001453941],"genre_scores_gemma":[0.9979154,0.0001747429,0.0006219086,0.00004393337,0.0002710362,0.000009457326,2.942599e-7,0.000005055919,0.0009582041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4029046,"threshold_uncertainty_score":0.2151109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04036966491226695,"score_gpt":0.336496499474529,"score_spread":0.296126834562262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}