{"id":"W4313532405","doi":"10.1136/lupus-2022-lupus21century.59","title":"908 The association between Systemic lupus Erythematosus (SLE) and bone mineral density (BMD) polygenic risk scores with lumbar spine BMD z-score: a retrospective cohort study","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"","keywords":"Medicine; Bone mineral; Internal medicine; Cohort; Femoral neck; Genome-wide association study; Osteoporosis; Rheumatology; Systemic lupus erythematosus; Single-nucleotide polymorphism; Oncology; Disease; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00257032,0.0003793668,0.001008239,0.0002178535,0.000697055,0.00008439667,0.0003016073,0.0001276285,0.00003959574],"category_scores_gemma":[0.0003951334,0.0002728636,0.0001249112,0.0007674636,0.000147975,0.00004424893,0.0005159984,0.0008838739,0.00001703276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001475845,"about_ca_system_score_gemma":0.0002925823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003234318,"about_ca_topic_score_gemma":0.0004982619,"domain_scores_codex":[0.9947703,0.0008065792,0.0006827111,0.0007752631,0.002273466,0.00069171],"domain_scores_gemma":[0.9974858,0.0001939218,0.0005863334,0.001046329,0.000447303,0.0002403122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001886573,0.0001941065,0.9924889,0.0001773382,0.001182137,0.0001450556,0.002953535,0.00003014891,0.001167379,0.00001468564,0.001357409,0.0001006054],"study_design_scores_gemma":[0.00433483,0.001951849,0.9727785,0.0001270785,0.001271949,0.0145183,0.004205611,0.0002486778,0.0001591431,0.00004623293,0.00006098849,0.0002968204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915354,0.002870155,0.00009479996,0.0002047705,0.0003931711,0.004567854,0.00009472259,0.0001068216,0.0001323158],"genre_scores_gemma":[0.9958353,0.0003433079,0.0001946704,0.0000431964,0.0004456996,0.0003879801,0.0000438436,0.00009466684,0.002611338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01971043,"threshold_uncertainty_score":0.9999723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245050243129346,"score_gpt":0.2535033860984819,"score_spread":0.2410528836671885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}