{"id":"W4313532405","doi":"10.1136/lupus-2022-lupus21century.59","title":"908 The association between Systemic lupus Erythematosus (SLE) and bone mineral density (BMD) polygenic risk scores with lumbar spine BMD z-score: a retrospective cohort study","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"","keywords":"Medicine; Bone mineral; Internal medicine; Cohort; Femoral neck; Genome-wide association study; Osteoporosis; Rheumatology; Systemic lupus erythematosus; Single-nucleotide polymorphism; Oncology; Disease; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001739865,0.0005306079,0.0006224891,0.001189463,0.0008304465,0.0009225462,0.0006601854,0.000683504,0.001902528],"category_scores_gemma":[0.00297679,0.0006727502,0.000981854,0.001965315,0.0003237888,0.0004254369,0.0005945148,0.0006653231,0.000484257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127088,"about_ca_system_score_gemma":0.0004217508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006829506,"about_ca_topic_score_gemma":0.00633911,"domain_scores_codex":[0.9984686,0.0003631722,0.0002348097,0.0005592731,0.0002325386,0.0001415432],"domain_scores_gemma":[0.9978583,0.0003557812,0.0008413894,0.0004148284,0.0002764212,0.0002531861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001797537,0.00002503193,0.9985455,0.00001562813,0.0003152461,0.00007243092,0.00002981434,0.00002930065,0.0001744172,0.00001386329,0.0001288344,0.0004702464],"study_design_scores_gemma":[0.00004598491,0.0001809258,0.9980065,0.00001250422,0.0003476236,0.0005579033,0.000063445,0.0003318481,0.00006734647,0.00003706351,0.000340021,0.000008907391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966643,0.0006129025,0.0003955179,0.00005002011,0.00001222975,0.00003583132,0.00189911,0.00001073746,0.0003191878],"genre_scores_gemma":[0.9982128,0.0001686245,0.0002956278,0.00004391493,0.00001873405,0.00005054022,0.001034333,0.000005580463,0.0001699673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006829506,"threshold_uncertainty_score":0.01357949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245050243129346,"score_gpt":0.2535033860984819,"score_spread":0.2410528836671885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}