{"id":"W4313532950","doi":"10.7150/ijbs.78785","title":"1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice","year":2023,"lang":"en","type":"article","venue":"International Journal of Biological Sciences","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Chondrocyte; Cartilage; Osteoarthritis; Calcitriol receptor; Senescence; Phenotype; Internal medicine; Endocrinology; Mesenchymal stem cell; Knockout mouse; Downregulation and upregulation; Aggrecan; Chemistry; Cancer research; Vitamin D and neurology; Medicine; Cell biology; Biology; Pathology; Gene; Biochemistry; Articular cartilage; Anatomy; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003815521,0.000617561,0.0006173268,0.001831916,0.0002926184,0.0004954216,0.0004035706,0.0007166,0.003582647],"category_scores_gemma":[0.0001869185,0.0005765933,0.000820156,0.0005164881,0.0005247506,0.0003804498,0.0002704188,0.001242547,0.0008059012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003917754,"about_ca_system_score_gemma":0.0004606219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305601,"about_ca_topic_score_gemma":0.002935147,"domain_scores_codex":[0.9996226,0.00004422349,0.00004881071,0.0001029121,0.000111422,0.00006997682],"domain_scores_gemma":[0.9997123,0.00001359058,0.0001160148,0.00002915861,0.0000283904,0.0001006417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007806263,0.0001380735,0.0006430643,0.00009251589,0.00002727302,0.00008287971,0.00002435595,0.00004137641,0.9956813,0.0001064619,0.000115304,0.00226675],"study_design_scores_gemma":[0.0006525891,0.002726136,0.04278413,0.00007364818,0.0003399896,0.001000288,0.0002079116,0.00154076,0.9394897,0.000499185,0.01063611,0.00004946203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978498,0.00741316,0.006945726,0.000636809,0.0002247629,0.00008914423,0.003000983,0.0006421416,0.002549132],"genre_scores_gemma":[0.978466,0.003773891,0.004763341,0.0003042155,0.00005660943,0.0001575898,0.001577494,0.0001210006,0.01078001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003582647,"threshold_uncertainty_score":0.01198518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05191134218418755,"score_gpt":0.36011132713607,"score_spread":0.3081999849518825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}