{"id":"W4313537466","doi":"10.1016/j.molstruc.2023.134924","title":"Design, synthesis, in vitro anti-oxidant evaluation, α-amylase inhibition assay, and molecular docking analysis of 2-(2-benzylidenehydrazinyl)-4,4-diphenyl-1H-imidazol-5(4H)-ones","year":2023,"lang":"en","type":"article","venue":"Journal of Molecular Structure","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"","keywords":"Chemistry; DPPH; Acarbose; Amylase; Docking (animal); IC50; In vitro; Enzyme; Antioxidant; Combinatorial chemistry; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001071207,0.0003235366,0.0008851542,0.001181445,0.00008231168,0.0001053682,0.0002605245,0.0002422563,0.0003201969],"category_scores_gemma":[0.0006339758,0.0003005961,0.0003548783,0.00119774,0.00006807956,0.0002167541,0.0000927919,0.0003247413,9.016803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182187,"about_ca_system_score_gemma":0.0001167864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001068797,"about_ca_topic_score_gemma":0.000004772788,"domain_scores_codex":[0.9967157,0.0003540784,0.001151073,0.0003647344,0.001102739,0.0003116283],"domain_scores_gemma":[0.9976282,0.0003287718,0.00108493,0.0003875064,0.000434824,0.0001358267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078901,0.00005160554,0.001299128,0.00008878588,0.0008060334,0.0003048161,0.0002421781,0.03152987,0.9610791,0.00001496288,0.00001608082,0.004459544],"study_design_scores_gemma":[0.0006769659,0.00002026397,0.01015648,0.000231814,0.001398032,0.0001160795,0.0002178773,0.02184512,0.9644064,0.0006128291,0.00004070022,0.0002774035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957424,0.000664716,0.002954553,0.0003122076,0.000085654,0.0001120759,0.00004499124,0.0000236943,0.00005975516],"genre_scores_gemma":[0.9988322,0.0001509656,0.0007801385,0.00006395319,0.00006087203,0.000009173393,0.00005685364,0.00004304038,0.000002758746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009684755,"threshold_uncertainty_score":0.9999446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332684443769454,"score_gpt":0.2573827780575129,"score_spread":0.2440559336198184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}