{"id":"W4313544615","doi":"10.1038/s41586-022-05580-6","title":"A DNA methylation atlas of normal human cell types","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":627,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Leibniz-Gemeinschaft; Stichting Diabetes Onderzoek Nederland; Israel Science Foundation; Human Islet Research Network; National Institute of Diabetes and Digestive and Kidney Diseases; Hadassah Medical Organization; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"DNA methylation; Biology; Chromatin; Epigenetics; Epigenomics; CpG site; Genetics; Epigenetics of physical exercise; Methylation; Enhancer; Differentially methylated regions; Computational biology; Regulation of gene expression; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401529,0.00006372581,0.00006686839,0.0000489059,0.00003862806,0.000005702689,0.00008009873,0.0005730591,0.00001970782],"category_scores_gemma":[0.00003617697,0.00006006792,0.00005070704,0.000148654,0.00001745053,0.000001698276,0.00004311263,0.0002078234,0.00001295446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003172302,"about_ca_system_score_gemma":0.00001723547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004796017,"about_ca_topic_score_gemma":0.0000134499,"domain_scores_codex":[0.9995266,0.00002595908,0.0001064145,0.0001374534,0.0001046286,0.00009896641],"domain_scores_gemma":[0.9996898,0.000006632168,0.0000584842,0.0001557448,0.00006446908,0.00002491446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009172792,0.00001255301,0.002038373,0.00001616206,0.000009179767,4.909277e-7,0.00003180156,0.0001703245,0.9955305,0.0001190238,0.001166772,0.0008956706],"study_design_scores_gemma":[0.0001677174,0.00009315722,0.03022728,0.000003135514,0.000008832909,1.337248e-7,0.00001004113,0.0000441587,0.9477443,0.0003666747,0.02126653,0.0000680694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920474,0.001432133,0.00009183517,0.00007160605,0.0001167173,0.00006338263,0.00001278444,0.00001215367,0.006151997],"genre_scores_gemma":[0.9974611,0.0001180954,0.0002024131,0.00002608102,0.0001518044,0.000002944902,0.0003260858,0.00001105757,0.001700416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04778621,"threshold_uncertainty_score":0.4419957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007973071136316333,"score_gpt":0.2760977527922245,"score_spread":0.2681246816559082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}