{"id":"W4313544615","doi":"10.1038/s41586-022-05580-6","title":"A DNA methylation atlas of normal human cell types","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":627,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Leibniz-Gemeinschaft; Stichting Diabetes Onderzoek Nederland; Israel Science Foundation; Human Islet Research Network; National Institute of Diabetes and Digestive and Kidney Diseases; Hadassah Medical Organization; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"DNA methylation; Biology; Chromatin; Epigenetics; Epigenomics; CpG site; Genetics; Epigenetics of physical exercise; Methylation; Enhancer; Differentially methylated regions; Computational biology; Regulation of gene expression; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004758182,0.0003309248,0.0005305707,0.002815589,0.0004864742,0.0005810315,0.000631244,0.0004170406,0.00554513],"category_scores_gemma":[0.000716655,0.0002857846,0.0003889735,0.002757039,0.0001981676,0.0003144143,0.0008080709,0.0005173213,0.00261882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005278491,"about_ca_system_score_gemma":0.0009198472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003003478,"about_ca_topic_score_gemma":0.006150391,"domain_scores_codex":[0.9995493,0.00006628983,0.00003841643,0.0001771229,0.0001242423,0.00004464125],"domain_scores_gemma":[0.999546,0.0000832245,0.00006691551,0.0001298159,0.0001156503,0.00005827692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001103103,0.00008200956,0.05933494,0.001917488,0.0006787116,0.000818353,0.0005181241,0.005788447,0.6112799,0.006456919,0.04821804,0.263804],"study_design_scores_gemma":[0.00009004689,0.0002794503,0.2814124,0.0002308936,0.0005096058,0.005809013,0.000180351,0.0107916,0.1578636,0.008348708,0.5343678,0.0001166134],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.3023606,0.02335003,0.2295104,0.0007563704,0.0003146363,0.0006269673,0.3891975,0.01143635,0.04244722],"genre_scores_gemma":[0.4750782,0.009558858,0.1858606,0.000664275,0.0001690827,0.001616939,0.306462,0.001133575,0.01945658],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00554513,"threshold_uncertainty_score":0.01855034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007973071136316333,"score_gpt":0.2760977527922245,"score_spread":0.2681246816559082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}