{"id":"W4313544669","doi":"10.1073/pnas.2217111120","title":"Similar evolutionary trajectories in an environmental <i>Cryptococcus neoformans</i> isolate after human and murine infection","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Broad Institute; National Institute of Neurological Disorders and Stroke; Canadian Institute for Advanced Research","keywords":"Biology; Virulence; Cryptococcus neoformans; Frameshift mutation; Gene; Nonsynonymous substitution; Phenotype; Genetics; Genome; Microbiology; Whole genome sequencing; Strain (injury); Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119321,0.0001728899,0.0001986034,0.0005259818,0.000386506,0.0003890852,0.0001186787,0.000311542,0.0008116014],"category_scores_gemma":[0.0004558425,0.00007075219,0.0001955119,0.0005401545,0.0001778462,0.0001234601,0.0002538411,0.000290032,0.0002069356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122236,"about_ca_system_score_gemma":0.0001357128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002154133,"about_ca_topic_score_gemma":0.002753818,"domain_scores_codex":[0.9998103,0.00003007505,0.00001566287,0.0000666355,0.00002741641,0.00005003378],"domain_scores_gemma":[0.9997914,0.00004000273,0.00006720223,0.00002167717,0.00003409582,0.00004554343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00109794,0.0001926149,0.4484966,0.0000987439,0.0001238026,0.004508735,0.00110947,0.0006873967,0.5272719,0.0004382271,0.0003589228,0.01561562],"study_design_scores_gemma":[0.00001382843,0.0003814576,0.9663646,0.00001906572,0.0000484827,0.01076446,0.0007684503,0.0006654243,0.01805166,0.00009156721,0.002811618,0.0000194157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989511,0.00008363446,0.0002097853,0.00001928843,0.000002884653,0.000008560004,0.0002661132,0.00000314741,0.0004554586],"genre_scores_gemma":[0.9972493,0.0001538162,0.0007820704,0.00004190045,0.000006002304,0.000009177942,0.001317166,0.000008892122,0.0004317279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154133,"threshold_uncertainty_score":0.00428313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117297753673661,"score_gpt":0.3074213349624646,"score_spread":0.276248357425728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}