{"id":"W4313544913","doi":"10.1128/spectrum.03789-22","title":"Validation and Establishment of the SARS-CoV-2 Lentivirus Surrogate Neutralization Assay as a Prescreening Tool for the Plaque Reduction Neutralization Test","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Neutralization; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Lentivirus; 2019-20 coronavirus outbreak; Immunization; Medicine; Human immunodeficiency virus (HIV); Immunology; Virus; Viral disease; Internal medicine; Outbreak; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007968553,0.0001595418,0.0002170558,0.0001735205,0.0002514503,0.00004863791,0.0001610441,0.0001591012,0.000004193618],"category_scores_gemma":[0.0003314206,0.0001058623,0.00009982454,0.000622995,0.0002171142,0.0001288782,0.00009802987,0.0001769646,0.00001358605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008268512,"about_ca_system_score_gemma":0.000125733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003326415,"about_ca_topic_score_gemma":0.0001171106,"domain_scores_codex":[0.9987167,0.0001705714,0.0003241865,0.000344023,0.0001077898,0.0003367321],"domain_scores_gemma":[0.999013,0.0003689919,0.0001673486,0.0003270078,0.0001137206,0.000009922492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002102395,0.00006138273,0.0202682,0.00007550015,0.00006411866,0.000001426167,0.000281412,0.00002208436,0.9758809,0.000714459,0.001825556,0.0005947782],"study_design_scores_gemma":[0.001046987,0.000277739,0.01147443,0.00006197166,0.0001058556,0.0001084415,0.0001153056,0.001127297,0.9706947,0.0004320339,0.01445053,0.0001047125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912379,0.0001193514,0.001766691,0.004765603,0.00033932,0.001536588,0.00005045131,0.00008705023,0.00009703731],"genre_scores_gemma":[0.9975531,0.00004702225,0.00005283222,0.001826396,0.0001418343,0.0001122831,0.0001164761,0.00002806123,0.0001219781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01262497,"threshold_uncertainty_score":0.4316939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696254486957585,"score_gpt":0.321639288083851,"score_spread":0.2846767432142752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}