{"id":"W4313545169","doi":"10.1128/aac.01294-22","title":"Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in <i>Mycobacterium tuberculosis</i> by the Novel Drug Candidate GSK2556286","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Lung Association; Government of Canada","keywords":"Mycobacterium tuberculosis; Catabolism; Drug; Microbiology; Tuberculosis; Pharmacology; Cholesterol; Chemistry; Biology; Virology; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149712,0.0002366619,0.0002340198,0.0002013638,0.0001470413,0.0002742527,0.0002319026,0.0002912226,0.002474042],"category_scores_gemma":[0.0001679348,0.0001200499,0.0002319004,0.000151447,0.0002510432,0.0001646148,0.0001769753,0.0008240902,0.000500401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148492,"about_ca_system_score_gemma":0.0004948662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000828672,"about_ca_topic_score_gemma":0.002170936,"domain_scores_codex":[0.9999223,0.00001345098,0.000009038209,0.00001183132,0.00001646408,0.00002691767],"domain_scores_gemma":[0.9999435,0.000007511112,0.00002081779,0.000005714453,0.000004508428,0.00001788551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00269829,0.0002824012,0.000680015,0.0002543969,0.00002674633,0.0002089063,0.00002522914,0.0004494582,0.9696118,0.0005991239,0.001226324,0.02393745],"study_design_scores_gemma":[0.001602742,0.01000574,0.01253648,0.00008089801,0.00008163427,0.001509208,0.00006733694,0.002129157,0.954447,0.0004756264,0.01703578,0.00002843158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728044,0.01350145,0.001919233,0.001392868,0.0003368134,0.0001456183,0.001285449,0.0002396173,0.008374668],"genre_scores_gemma":[0.9895539,0.004899282,0.001891864,0.0002807333,0.00005727207,0.00006123717,0.0007082308,0.00001191627,0.002535479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002474042,"threshold_uncertainty_score":0.008276463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587835424136128,"score_gpt":0.2874998527100493,"score_spread":0.271621498468688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}