{"id":"W4313545337","doi":"10.1126/sciadv.abn9793","title":"In vitro cellular reprogramming to model gonad development and its disorders","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Institute of Genetics; Institut National de la Recherche Agronomique; Agence Nationale de la Recherche; Wellcome Trust; Francis Crick Institute; British Heart Foundation; Bar-Ilan University; Cancer Research UK; University of Minnesota","keywords":"Biology; Reprogramming; Gonad; Embryonic stem cell; Transcriptome; Induced pluripotent stem cell; Cell biology; Gonadal ridge; Disorders of sex development; Sertoli cell; Sexual differentiation; Progenitor cell; Somatic cell; Genetics; Gene; Stem cell; Endocrinology; Gene expression; Spermatogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293523,0.00006522344,0.00006059954,0.00006167734,0.0001121443,0.00002376373,0.000152958,0.00002338418,0.000002265287],"category_scores_gemma":[0.00007233401,0.00005861768,0.00001265324,0.0002761171,0.0001109045,0.00001621711,0.0001289517,0.00002701158,0.00001484228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005906446,"about_ca_system_score_gemma":0.00006126385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001492176,"about_ca_topic_score_gemma":0.00002168658,"domain_scores_codex":[0.9991968,0.000005542634,0.0001261167,0.0003085127,0.0001386362,0.000224342],"domain_scores_gemma":[0.9997767,0.000005852894,0.00002087191,0.00008575246,0.00002769508,0.0000831528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001814358,0.00002065019,0.0002682008,0.00001349316,0.000001219358,0.000002116132,0.0003190237,0.0008872665,0.9075339,0.00017804,0.00001361144,0.09074436],"study_design_scores_gemma":[0.0001185422,0.00005775056,0.0007782596,0.000006581886,7.210235e-7,6.251427e-7,0.0006844803,0.001059024,0.980426,0.0008032363,0.01594108,0.0001237244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982359,0.0004045987,0.0003065581,0.000398583,0.00006624792,0.00008205506,0.000001342038,0.00001094139,0.000493767],"genre_scores_gemma":[0.9954448,0.00009890657,0.002449498,0.0002495193,0.00001977062,0.0000238586,0.000004494331,0.000003587542,0.001705536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09062064,"threshold_uncertainty_score":0.2390359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400156723488293,"score_gpt":0.2914249800724965,"score_spread":0.2774234128376135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}