{"id":"W4313545337","doi":"10.1126/sciadv.abn9793","title":"In vitro cellular reprogramming to model gonad development and its disorders","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Institute of Genetics; Institut National de la Recherche Agronomique; Agence Nationale de la Recherche; Wellcome Trust; Francis Crick Institute; British Heart Foundation; Bar-Ilan University; Cancer Research UK; University of Minnesota","keywords":"Biology; Reprogramming; Gonad; Embryonic stem cell; Transcriptome; Induced pluripotent stem cell; Cell biology; Gonadal ridge; Disorders of sex development; Sertoli cell; Sexual differentiation; Progenitor cell; Somatic cell; Genetics; Gene; Stem cell; Endocrinology; Gene expression; Spermatogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357983,0.0004414755,0.0002744303,0.0004029571,0.0003287143,0.0004368657,0.0004491157,0.0005055066,0.002953388],"category_scores_gemma":[0.0001849612,0.000224712,0.0004483577,0.000256933,0.0003301785,0.0001674254,0.000500777,0.001061739,0.001498789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551158,"about_ca_system_score_gemma":0.0002844791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006813538,"about_ca_topic_score_gemma":0.001337327,"domain_scores_codex":[0.9996148,0.00007651253,0.00004477517,0.00007328473,0.0001509343,0.00003960377],"domain_scores_gemma":[0.9998153,0.00003493998,0.00003719086,0.00005981452,0.0000204737,0.00003229442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005804809,0.00007549838,0.0002580421,0.0001428142,0.00001385699,0.0002919594,0.00008026788,0.0007796441,0.9902248,0.002976584,0.0005650533,0.004533497],"study_design_scores_gemma":[0.00002810567,0.000368451,0.001595606,0.00005185941,0.0000537146,0.001444332,0.00006368312,0.003050568,0.9127218,0.0008494274,0.07975563,0.00001686938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6184067,0.01350718,0.2682971,0.001232286,0.001931319,0.001770089,0.01193344,0.002687205,0.08023466],"genre_scores_gemma":[0.8703836,0.008423621,0.08413377,0.0005317617,0.00009688794,0.001516187,0.006442791,0.000389014,0.02808245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953388,"threshold_uncertainty_score":0.009880066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400156723488293,"score_gpt":0.2914249800724965,"score_spread":0.2774234128376135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}