{"id":"W4313545983","doi":"10.1172/jci165245","title":"Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Clinique Paro Excellence","funders":"National Institute of General Medical Sciences; NIH Office of the Director; National Heart, Lung, and Blood Institute; Center for AIDS Research, University of Washington; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; Howard Hughes Medical Institute","keywords":"Viremia; Virology; Biology; Viral load; Antiretroviral therapy; Viral replication; Human immunodeficiency virus (HIV); Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001233008,0.0001477961,0.0004164517,0.0002329722,0.0001372653,0.00003357043,0.0002098491,0.0002100283,0.0001170541],"category_scores_gemma":[0.00170423,0.00009795634,0.0001236062,0.0003449,0.000337074,0.0001567334,0.00005885179,0.0006073791,0.00127523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004588713,"about_ca_system_score_gemma":0.0007990916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003308609,"about_ca_topic_score_gemma":0.0001309657,"domain_scores_codex":[0.9978351,0.000596232,0.000825925,0.0002232954,0.000176737,0.000342738],"domain_scores_gemma":[0.997897,0.0009423688,0.0004195173,0.0001887768,0.0003213267,0.0002310513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004255312,0.0004618431,0.6856688,0.00006045714,0.001065594,0.0004465215,0.002145212,0.0003468082,0.1016783,0.000169215,0.1969779,0.006724084],"study_design_scores_gemma":[0.009577917,0.005900574,0.8200598,0.0005147296,0.0002567252,0.0002145955,0.0006458928,0.00001156471,0.1336173,0.00119275,0.02765767,0.0003504927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99373,0.000169653,0.00004428135,0.005175414,0.0002861767,0.0002887564,0.00005641975,0.00003903903,0.0002102584],"genre_scores_gemma":[0.9959102,0.00007546408,0.0009375467,0.0005407039,0.0002142489,0.00002249348,0.00009102321,0.00001914812,0.002189185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1693202,"threshold_uncertainty_score":0.9995024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0885554254870092,"score_gpt":0.3778661466894443,"score_spread":0.2893107212024351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}