{"id":"W4313546100","doi":"10.1128/iai.00423-22","title":"MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony Variants <i>In Vitro</i> within Macrophages and Endothelial Cells during Prolonged Vancomycin Exposure","year":2023,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Congressionally Directed Medical Research Programs; Clinical and Translational Science Institute, University of California, Los Angeles; National Institutes of Health; Allergan; Genentech; Canadian Institutes of Health Research; Regeneron Pharmaceuticals; National Center for Advancing Translational Sciences; Infectious Diseases Society of America; National Institute of Allergy and Infectious Diseases; Pfizer; Government of Canada; U.S. Department of Defense","keywords":"Bacteremia; Biology; Microbiology; In vitro; Vancomycin; Bacteria; Antibiotics; Immunology; Virology; Staphylococcus aureus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718315,0.0001947849,0.0002077187,0.0001271402,0.0001479957,0.00032414,0.00009775622,0.0002234,0.001945386],"category_scores_gemma":[0.0005011692,0.0001366699,0.0001660526,0.00009912096,0.0001608949,0.0001198212,0.0002050751,0.0003604264,0.0004611292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001132804,"about_ca_system_score_gemma":0.0001285477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149576,"about_ca_topic_score_gemma":0.001458835,"domain_scores_codex":[0.9997794,0.00005173369,0.00002669908,0.00004413705,0.00004034257,0.00005771151],"domain_scores_gemma":[0.9997185,0.00005898957,0.0000662647,0.00004369254,0.0000392193,0.00007329456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006536017,0.0001552625,0.02344897,0.00005558661,0.00002879184,0.0006890538,0.0002463826,0.00009510233,0.9690366,0.0001494486,0.0004531434,0.004988049],"study_design_scores_gemma":[0.0001006324,0.005751607,0.4573231,0.0000567461,0.00007718574,0.01179727,0.001598704,0.002775912,0.5123852,0.0003472575,0.007752343,0.00003408539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985167,0.0002330876,0.0005395925,0.00005792455,0.0000142279,0.0000130834,0.0001102237,0.00001477034,0.0005002551],"genre_scores_gemma":[0.9986473,0.00005735776,0.0004014202,0.0000492459,0.000007360174,0.000008977021,0.0002586889,0.000005684438,0.0005638814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945386,"threshold_uncertainty_score":0.006507933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008811365720432411,"score_gpt":0.203100606318789,"score_spread":0.1942892405983566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}