{"id":"W4313546351","doi":"10.1200/jco.22.00655","title":"Development and Validation of a Genomic Profile for the Omission of Local Adjuvant Radiation in Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Gunnar Nilssons Cancerstiftelse; Lunds Universitet; Cancerfonden","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Cohort; Hazard ratio; Proportional hazards model; Breast-conserving surgery; Tamoxifen; Radiation therapy; Adjuvant; Estrogen receptor; Cancer; Mastectomy; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001462745,0.0003074621,0.0005251149,0.000653194,0.0001511132,0.0005238578,0.0003071955,0.0002788877,0.0006281805],"category_scores_gemma":[0.003367027,0.00012426,0.0004408006,0.0006183827,0.0002734984,0.0001828941,0.0003397794,0.0003092283,0.0001687324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670432,"about_ca_system_score_gemma":0.0004638603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007519883,"about_ca_topic_score_gemma":0.001262813,"domain_scores_codex":[0.9994183,0.0002102603,0.00004478976,0.0001653164,0.0001207854,0.00004056247],"domain_scores_gemma":[0.9984156,0.0006145128,0.0005838434,0.0001486191,0.00015773,0.00007974832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002755444,0.0001697678,0.9000956,0.0002103722,0.0004055143,0.00009182186,0.00006357495,0.007066346,0.03154504,0.0001692338,0.0005367557,0.05689057],"study_design_scores_gemma":[0.0001940017,0.002128377,0.9546098,0.00005838762,0.0006843475,0.0005862574,0.0001378705,0.02330157,0.01511171,0.0006697243,0.002488823,0.00002915446],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926822,0.0007875099,0.003987754,0.0001371495,0.00001226259,0.00006190465,0.001842469,0.00003100123,0.0004577141],"genre_scores_gemma":[0.9948166,0.0001745634,0.002683582,0.00006941732,0.0000112447,0.00004628029,0.001998777,0.000006938393,0.0001926513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462745,"threshold_uncertainty_score":0.007735789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06752263489636273,"score_gpt":0.4249159020508733,"score_spread":0.3573932671545105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}