{"id":"W4313549090","doi":"10.1101/2023.01.02.522257","title":"HSV-1 Oncolytic Virus Targeting CEACAM6-Expressing Tumors Using a Bispecific T-Cell Engager","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Cancer research; T cell; In vitro; Cell; Molecular biology; Biology; Tumor cells; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138975,0.0003167387,0.0001389934,0.0001551861,0.00008795349,0.0003740403,0.0001376373,0.0003864745,0.0009066987],"category_scores_gemma":[0.0001010182,0.00009548481,0.0001938964,0.0001192356,0.0001696898,0.0001830731,0.0002139087,0.0005823996,0.0006298777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003000005,"about_ca_system_score_gemma":0.0001835286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006161274,"about_ca_topic_score_gemma":0.0004624649,"domain_scores_codex":[0.9998932,0.00001292361,0.000007413257,0.00002174358,0.00004115969,0.00002360485],"domain_scores_gemma":[0.9999745,0.000005007387,0.000006223746,0.000004949714,0.000003224237,0.00000616495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006164608,0.00001843,0.0001086516,0.00001853253,0.000004037291,0.00003425933,0.00001021581,0.0002192901,0.9977096,0.0003780444,0.00009583209,0.00134144],"study_design_scores_gemma":[0.00001122667,0.0001075829,0.000347996,0.000003167166,0.000004822246,0.0001531325,0.00000714323,0.001896053,0.993802,0.00007233704,0.003591972,0.000002593203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691872,0.001211614,0.02139948,0.0002047637,0.0000938539,0.000114577,0.0009672862,0.0002571019,0.006564211],"genre_scores_gemma":[0.9822711,0.0005033895,0.009809164,0.00005384002,0.00001222453,0.00003492429,0.0008678233,0.00003546117,0.006412062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009066987,"threshold_uncertainty_score":0.003033221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05696290364113694,"score_gpt":0.2948025157084825,"score_spread":0.2378396120673456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}