{"id":"W4313549583","doi":"10.1164/rccm.202206-1139le","title":"Identification of a Genetic Susceptibility Locus for Idiopathic Pulmonary Fibrosis in the 16p Subtelomere Using Whole-Genome Sequencing","year":2023,"lang":"en","type":"letter","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Heart, Lung, and Blood Institute; Genentech; National Institutes of Health; Pulmonary Fibrosis Foundation; U.S. Department of Veterans Affairs","keywords":"Locus (genetics); Medicine; Idiopathic pulmonary fibrosis; Whole genome sequencing; Genome; Genetics; Biology; Gene; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002561435,0.0005211073,0.0009162775,0.0006580254,0.002151298,0.001111654,0.0009255304,0.01992957,0.002056786],"category_scores_gemma":[0.009688316,0.000493087,0.0008581484,0.0003930258,0.00110814,0.0009866816,0.0005216862,0.0135932,0.002225109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002213926,"about_ca_system_score_gemma":0.002328871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009659473,"about_ca_topic_score_gemma":0.01875831,"domain_scores_codex":[0.9984987,0.0005158168,0.0002423282,0.0001675165,0.0004094558,0.0001662344],"domain_scores_gemma":[0.9961191,0.002349707,0.0001803967,0.0001129522,0.0007886231,0.0004492081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002826902,0.0001253396,0.006541179,0.00006512326,0.00003975646,0.01764633,0.0002196774,0.0001773656,0.001931363,0.002372513,0.9514806,0.01911809],"study_design_scores_gemma":[0.000845172,0.0009965202,0.02304674,0.0008427554,0.0002423757,0.04133478,0.001338025,0.005847771,0.003628115,0.01459844,0.9070613,0.0002180567],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.004905715,0.00172524,0.0005148988,0.9688496,0.01907567,0.00005778889,0.0002133575,0.00009326971,0.004564395],"genre_scores_gemma":[0.0271065,0.002278107,0.001143519,0.9181605,0.03743846,0.00008780117,0.0001875002,0.00003765493,0.01355999],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01992957,"threshold_uncertainty_score":0.01920646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03493101110736239,"score_gpt":0.3187487783842298,"score_spread":0.2838177672768674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}