{"id":"W4313551407","doi":"10.1101/2023.01.04.522747","title":"DNA supercoiling-induced shapes alter minicircle hydrodynamic properties","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institutes of Health; National Science Foundation","keywords":"DNA supercoil; Minicircle; DNA; Biophysics; Curvature; Physics; Geometry; Biology; Genetics; DNA replication; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088869,0.0002526596,0.0001147064,0.0001526773,0.0001484491,0.0002925402,0.0001861006,0.0002314007,0.001043281],"category_scores_gemma":[0.0007355784,0.0001743612,0.0001455637,0.0001393376,0.000363313,0.0002799709,0.0001505075,0.0004541873,0.0002463249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635279,"about_ca_system_score_gemma":0.0001564695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006871357,"about_ca_topic_score_gemma":0.0007355161,"domain_scores_codex":[0.9999189,0.00001595409,0.00000452781,0.00001636718,0.00002742896,0.00001676306],"domain_scores_gemma":[0.9997371,0.000100798,0.00005374769,0.0000334753,0.00004177886,0.00003300435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106517,0.0000171764,0.001296556,0.0000246012,0.000004285477,0.00003949155,0.00005807423,0.00195327,0.994495,0.0003403571,0.00009924293,0.001565611],"study_design_scores_gemma":[0.000006860773,0.00006064727,0.005290396,0.000003067084,0.000003562776,0.00006024428,0.00003768204,0.01141083,0.9820912,0.0002534691,0.0007714317,0.000010589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951201,0.0001493783,0.003893519,0.00005881105,0.00001887069,0.000007248289,0.0001625728,0.00008893161,0.000500467],"genre_scores_gemma":[0.9959471,0.0001592724,0.002620925,0.00002813004,0.000005617183,0.000009075731,0.0002619785,0.00006523132,0.0009028303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043281,"threshold_uncertainty_score":0.00349015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861626883359699,"score_gpt":0.2201207200961386,"score_spread":0.2015044512625417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}