{"id":"W4313554841","doi":"10.1016/s2213-8587(22)00353-9","title":"Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Novartis Pharma; National Institute for Health and Care Research; Novartis","keywords":"Medicine; PCSK9; Clinical endpoint; Placebo; Statin; Population; Dosing; Internal medicine; Cholesterol; Adverse effect; Surrogate endpoint; Clinical trial; Lipoprotein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003639212,0.00103249,0.001673963,0.0001934168,0.0002749811,0.0009215355,0.0007581761,0.001138988,0.002661142],"category_scores_gemma":[0.001916078,0.0002764519,0.00175345,0.0003089077,0.000623939,0.0009387549,0.0004650574,0.002434177,0.0004706714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005210395,"about_ca_system_score_gemma":0.0006907732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003463734,"about_ca_topic_score_gemma":0.00106479,"domain_scores_codex":[0.9990454,0.0005659377,0.00005165215,0.0001229395,0.00008362379,0.0001303851],"domain_scores_gemma":[0.9983749,0.0003166589,0.0006018105,0.0002041953,0.0001040135,0.0003982887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9246985,0.009484265,0.009990129,0.0008700828,0.002026958,0.0001536115,0.0001841671,0.0006966021,0.008947906,0.0001341895,0.001401957,0.04141151],"study_design_scores_gemma":[0.7060678,0.2196445,0.06571153,0.000128443,0.002445845,0.0003420201,0.00009624587,0.0007526563,0.001938434,0.0002362052,0.002571349,0.00006496714],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945645,0.003245925,0.0001473247,0.0001899736,0.00006333542,0.0003672281,0.0004210873,0.00003405119,0.0009666732],"genre_scores_gemma":[0.9940654,0.001502803,0.0006620033,0.0005137289,0.0002167793,0.0006408611,0.001411316,0.00001513722,0.0009719086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003639212,"threshold_uncertainty_score":0.01924622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02597753939457765,"score_gpt":0.2666045048871705,"score_spread":0.2406269654925928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}