{"id":"W4313554841","doi":"10.1016/s2213-8587(22)00353-9","title":"Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Novartis Pharma; National Institute for Health and Care Research; Novartis","keywords":"Medicine; PCSK9; Clinical endpoint; Placebo; Statin; Population; Dosing; Internal medicine; Cholesterol; Adverse effect; Surrogate endpoint; Clinical trial; Lipoprotein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001582458,0.0001975503,0.001059814,0.00006103545,0.0001565626,0.00001718195,0.0004001532,0.00009427122,0.000002667468],"category_scores_gemma":[0.0004861345,0.00009172138,0.000102194,0.0004127144,0.0003502665,0.00005548788,0.000521134,0.0004401051,0.000001674546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889501,"about_ca_system_score_gemma":0.00005997008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001706932,"about_ca_topic_score_gemma":0.0001382104,"domain_scores_codex":[0.9972581,0.0008356487,0.0004980002,0.0004248263,0.0004340629,0.0005494226],"domain_scores_gemma":[0.9974441,0.0005285575,0.0002556514,0.001601445,0.0001158902,0.00005434964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03052545,0.000302435,0.9072991,0.0001056266,0.001667744,0.00001237632,0.0006189782,0.00005682179,0.0002803512,0.0000642715,0.0000990613,0.05896775],"study_design_scores_gemma":[0.1263375,0.000831778,0.8710552,0.0002568193,0.0004296385,0.00000232153,0.00003553548,0.000012937,0.0006098959,0.00007787469,0.0002632244,0.00008726164],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946291,0.001292751,0.000002596107,0.0009880787,0.0002134824,0.002593592,0.0002395756,0.00002658453,0.00001420305],"genre_scores_gemma":[0.9974272,0.001919296,0.00003182722,0.0001940581,0.0002431901,0.00004808676,0.0001030764,0.00002568579,0.000007601806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09581208,"threshold_uncertainty_score":0.374029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02597753939457765,"score_gpt":0.2666045048871705,"score_spread":0.2406269654925928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}