{"id":"W4313555640","doi":"10.1126/science.abj8894","title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Centre Hospitalier Universitaire Sainte-Justine; Montreal Clinical Research Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Neuroinflammation; Biology; TLR4; Innate immune system; Immunology; Epigenetics; Proinflammatory cytokine; Microglia; Inflammation; Neuroscience; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007724524,0.00011103,0.0001331717,0.0005978237,0.0001565178,0.00003596464,0.0003089547,0.00002736062,0.00002874982],"category_scores_gemma":[0.000608541,0.000110823,0.00002974205,0.001271443,0.0005097215,0.0003001588,0.0001489543,0.000115207,0.00002974693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070264,"about_ca_system_score_gemma":0.0001355957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009572171,"about_ca_topic_score_gemma":0.00002802266,"domain_scores_codex":[0.9984255,0.0001861059,0.0002404533,0.0004242264,0.0004563292,0.0002673248],"domain_scores_gemma":[0.9993132,0.0001390352,0.0001422689,0.0002671116,0.00004989106,0.0000884839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007880813,0.00001708837,0.0004385082,0.00001954948,2.02311e-7,0.00000685722,0.0009670615,0.0003355988,0.9963281,0.0007078045,0.00002969897,0.001141646],"study_design_scores_gemma":[0.0002366256,0.0001066135,0.02799889,0.00001420241,0.000002560616,0.000008642501,0.000112009,0.01444478,0.9561015,0.0002034413,0.0006566255,0.0001141514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980089,0.00004113086,0.00001616712,0.0006303299,0.0004959772,0.0002342663,0.000002845933,0.00009287,0.00047751],"genre_scores_gemma":[0.998631,0.0003096779,0.00003610383,0.0001750543,0.00001552184,0.00001197856,9.548307e-7,0.000008486848,0.000811195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04022665,"threshold_uncertainty_score":0.4519231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04660672172326302,"score_gpt":0.2498257066193038,"score_spread":0.2032189848960407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}