{"id":"W4313556534","doi":"10.18433/jpps33020","title":"Post-Marketing Safety of Vemurafenib: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Vemurafenib; Adverse Event Reporting System; Medicine; Pharmacovigilance; Adverse effect; Internal medicine; Pharmacology; Metastatic melanoma; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006964921,0.0001804046,0.0003993375,0.0001249043,0.0004542642,0.00001196751,0.0009419652,0.00001907051,0.000135263],"category_scores_gemma":[0.0004392237,0.0001251661,0.0003308055,0.0006134465,0.0002252098,0.00001853183,0.0005655858,0.0003957442,5.663934e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008250133,"about_ca_system_score_gemma":0.0004644843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007844881,"about_ca_topic_score_gemma":0.000013146,"domain_scores_codex":[0.9953529,0.0009686682,0.001949171,0.0003078739,0.001077116,0.0003442409],"domain_scores_gemma":[0.9959489,0.00014741,0.003215629,0.0002178613,0.0002977478,0.0001725049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001195982,0.0005150951,0.1349671,0.0001220771,0.0001308888,0.00005994882,0.0003082463,0.003676018,0.8539575,0.00003745071,0.0001761774,0.004853575],"study_design_scores_gemma":[0.005814878,0.001609276,0.02771052,0.0001641469,0.0004870774,0.0006828202,0.008502283,0.004047976,0.8948699,0.000005888109,0.05570828,0.0003969435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962091,0.0005501479,0.00002082692,0.0002738473,0.001067728,0.0003986938,0.00002364817,0.000006552701,0.001449454],"genre_scores_gemma":[0.9992297,0.00009954586,0.00009930672,0.0001870994,0.0002598149,0.00001113041,0.000001265165,0.00001245447,0.0000996567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1072565,"threshold_uncertainty_score":0.5104123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0480715049185764,"score_gpt":0.377340102878392,"score_spread":0.3292685979598156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}