{"id":"W4313558367","doi":"10.3390/biomedicines11010134","title":"Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPD","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"COPD; Epigenetics; DNA methylation; Medicine; Epigenome; Airway; Lung cancer; Clinical significance; Internal medicine; Bioinformatics; Immunology; Biology; Anesthesia; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573448,0.0001075846,0.000162899,0.0001381577,0.00006416373,0.00001032086,0.00004617905,0.00007955854,0.000002603006],"category_scores_gemma":[0.00009559065,0.00008535881,0.00001581852,0.0003929317,0.00007187952,0.000001730646,0.00003300536,0.00004143665,0.00000420013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002490603,"about_ca_system_score_gemma":0.00007370143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008977517,"about_ca_topic_score_gemma":0.0008374091,"domain_scores_codex":[0.9991,0.00007052251,0.0001979926,0.0002421315,0.0001177042,0.0002716463],"domain_scores_gemma":[0.9995583,0.00002592552,0.0001059282,0.000152606,0.00004841154,0.0001088302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004429671,0.00008274466,0.803807,0.0001546028,0.00006375426,0.00001341245,0.0005487676,0.0001555903,0.1849719,0.00002197414,0.001566847,0.008569086],"study_design_scores_gemma":[0.001251836,0.0006544455,0.9883347,0.0003065728,0.0000136446,0.000003578024,0.0009123557,0.0002317264,0.003750797,0.00004093581,0.004306795,0.000192605],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990012,0.008631278,0.0002555707,0.0006491198,0.0001053651,0.0002196944,0.00004358643,0.0000244796,0.00005889538],"genre_scores_gemma":[0.996061,0.002931723,0.00004377107,0.00007994672,0.00008383041,0.00002661048,0.0003832706,0.00001730633,0.0003726018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1845277,"threshold_uncertainty_score":0.3480831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680208800008285,"score_gpt":0.2861975117237049,"score_spread":0.269395423723622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}