{"id":"W4313558367","doi":"10.3390/biomedicines11010134","title":"Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPD","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"COPD; Epigenetics; DNA methylation; Medicine; Epigenome; Airway; Lung cancer; Clinical significance; Internal medicine; Bioinformatics; Immunology; Biology; Anesthesia; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813178,0.0001087852,0.0002615973,0.0003983953,0.0001647863,0.000248877,0.000103133,0.0002484991,0.00150712],"category_scores_gemma":[0.0005810966,0.0001064992,0.0001802121,0.0005148562,0.0001683696,0.0001362396,0.0002722379,0.0002406032,0.0001504621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001067015,"about_ca_system_score_gemma":0.00009264331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008984212,"about_ca_topic_score_gemma":0.001881232,"domain_scores_codex":[0.9998496,0.00002502562,0.00001239077,0.0000616944,0.00002792145,0.00002344905],"domain_scores_gemma":[0.9997291,0.00005657223,0.0001304594,0.00002251282,0.00002767828,0.00003371404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006489986,0.0000411403,0.9148256,0.00008743747,0.0001771147,0.0001694596,0.0001905756,0.0001385153,0.06561752,0.0001059216,0.0001665505,0.01783119],"study_design_scores_gemma":[0.000002576282,0.00005809715,0.9977816,0.000004367312,0.00003324826,0.0001927791,0.00005100447,0.0001315112,0.001451864,0.00008011009,0.0002104849,0.000002335976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974558,0.001231542,0.0003775651,0.00004524548,0.000003931661,0.000004231998,0.00039197,0.000006148694,0.0004835839],"genre_scores_gemma":[0.9990119,0.0002553108,0.0002104369,0.00002565894,0.000005461895,0.000005012796,0.0002069047,0.000002193634,0.0002771531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150712,"threshold_uncertainty_score":0.005041838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680208800008285,"score_gpt":0.2861975117237049,"score_spread":0.269395423723622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}