{"id":"W4313559124","doi":"10.3390/v15010161","title":"Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection","year":2023,"lang":"en","type":"review","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nucleoprotein; Biology; Epigenetics; Virology; Viral replication; Gene; Virus; DNA; DNA virus; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"not_applicable","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000340301,0.0005714701,0.0008746881,0.001445692,0.0001931338,0.0008668487,0.0004942609,0.0005784337,0.001989464],"category_scores_gemma":[0.0003246719,0.0002360935,0.000284311,0.00139226,0.0002842349,0.0008046393,0.0004329535,0.001018275,0.001997427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006253115,"about_ca_system_score_gemma":0.0007912423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009231974,"about_ca_topic_score_gemma":0.001183776,"domain_scores_codex":[0.9998963,0.00001174398,0.00001472213,0.00002106922,0.00004347028,0.00001258382],"domain_scores_gemma":[0.99989,0.00004148562,0.00001479805,0.000003320916,0.00003850443,0.00001187862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007526068,0.00004536028,0.0002131614,0.01378147,0.00005230834,0.0001522835,0.00007468474,0.0004069105,0.01051464,0.003970748,0.01592224,0.9547909],"study_design_scores_gemma":[0.000006369472,0.00007815581,0.0006038716,0.001140881,0.00004919269,0.0006731167,0.00004253328,0.00006221166,0.002232682,0.0009579302,0.9941369,0.00001605058],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002407128,0.9978655,0.0002151518,0.0001280808,0.0001672814,0.000005634491,0.00003276169,0.00001090186,0.001334121],"genre_scores_gemma":[0.0006941794,0.9984309,0.000159655,0.00006040192,0.00005199458,0.00000567156,0.00004140652,0.000001349374,0.0005543524],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001989464,"threshold_uncertainty_score":0.006655395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07116919684605096,"score_gpt":0.4083957818780681,"score_spread":0.3372265850320171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}