{"id":"W4313559124","doi":"10.3390/v15010161","title":"Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection","year":2023,"lang":"en","type":"review","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nucleoprotein; Biology; Epigenetics; Virology; Viral replication; Gene; Virus; DNA; DNA virus; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"not_applicable","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002732251,0.0004771378,0.0007289373,0.0002404928,0.0001714253,0.00006806503,0.0003041434,0.0008456603,0.00005937195],"category_scores_gemma":[0.00006663738,0.0004222071,0.0001309869,0.0004839891,0.0001259922,0.00001439616,0.0003044849,0.0003829652,0.00002907289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009525799,"about_ca_system_score_gemma":0.0001137562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000352425,"about_ca_topic_score_gemma":0.002326405,"domain_scores_codex":[0.997426,0.0003192882,0.0004662364,0.001147627,0.0002569406,0.0003839257],"domain_scores_gemma":[0.9982851,0.00001736756,0.000327106,0.001243973,0.00006217128,0.00006428337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001101486,0.0000413098,0.0000250639,0.002432368,0.0001328544,0.000005961952,0.00008683251,0.000003520397,0.7797091,0.000005761633,0.0004684191,0.2169787],"study_design_scores_gemma":[0.0005148608,0.0009545594,0.0001050487,0.002609481,0.0001093784,0.00002198811,0.00001052429,0.000004612257,0.4592431,0.0002688892,0.5354798,0.0006776506],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1139025,0.8841476,0.00001007828,0.0000401742,0.00008666886,0.001378735,0.0003367376,0.00008070846,0.00001678736],"genre_scores_gemma":[0.002391878,0.9953726,0.0001063756,0.0001772857,0.0002390263,0.0002767825,0.0009618177,0.0001735282,0.0003007125],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5350114,"threshold_uncertainty_score":0.999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07116919684605096,"score_gpt":0.4083957818780681,"score_spread":0.3372265850320171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}