{"id":"W4313574894","doi":"10.1021/acsomega.2c07484","title":"Synthesis, Radiolabeling, and <i>In Vitro</i> and <i>In Vivo</i> Characterization of Heterobivalent Peptidic Agents for Bispecific EGFR and Integrin α<sub>v</sub>β<sub>3</sub> Targeting","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bundesministerium für Bildung und Forschung","keywords":"In vivo; In vitro; Receptor; Chemistry; Epidermal growth factor receptor; Integrin; Peptide; Oligopeptide; Biochemistry; Cancer research; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406939,0.0003474175,0.0001715375,0.0001110048,0.00009163527,0.0001769065,0.0002199741,0.0002798391,0.0007266267],"category_scores_gemma":[0.000112964,0.000164704,0.0001382911,0.0001048333,0.0001288934,0.0001661612,0.0001037838,0.0002687617,0.0004547676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240061,"about_ca_system_score_gemma":0.0001446406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004254969,"about_ca_topic_score_gemma":0.0007532545,"domain_scores_codex":[0.9999362,0.00001252033,0.000004115367,0.00001387877,0.00001920137,0.00001396781],"domain_scores_gemma":[0.9999194,0.00001459634,0.00002858643,0.000007948423,0.00001439081,0.00001502712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003086596,0.000009278937,0.00002173677,0.00001849934,0.00000143687,0.00001708014,0.000005461369,0.0001004294,0.9988698,0.00002889987,0.00001655046,0.0008799912],"study_design_scores_gemma":[0.000007299076,0.0001614012,0.0002644022,0.000001463057,0.000005534356,0.00008841612,0.000004273879,0.0003852868,0.9979172,0.000009268771,0.00115299,0.000002381112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495211,0.002199216,0.04272189,0.0001005253,0.00002672919,0.0002797731,0.000419522,0.0002023519,0.004528827],"genre_scores_gemma":[0.934714,0.002505744,0.05404256,0.0002070321,0.00002071392,0.0002931234,0.0009658574,0.0001301211,0.007120972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007266267,"threshold_uncertainty_score":0.002430856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112515694893201,"score_gpt":0.2666427429955478,"score_spread":0.2455175860466158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}