{"id":"W4313574894","doi":"10.1021/acsomega.2c07484","title":"Synthesis, Radiolabeling, and <i>In Vitro</i> and <i>In Vivo</i> Characterization of Heterobivalent Peptidic Agents for Bispecific EGFR and Integrin α<sub>v</sub>β<sub>3</sub> Targeting","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Bundesministerium für Bildung und Forschung","keywords":"In vivo; In vitro; Receptor; Chemistry; Epidermal growth factor receptor; Integrin; Peptide; Oligopeptide; Biochemistry; Cancer research; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008886931,0.0002876479,0.00059626,0.0006908121,0.0000880177,0.00005442345,0.0001165935,0.0001783718,0.000002672304],"category_scores_gemma":[0.0005216813,0.0002806847,0.00006743075,0.000642067,0.0001490797,0.0001562481,0.0001996994,0.0003202994,0.000007205822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089163,"about_ca_system_score_gemma":0.00005717871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001184181,"about_ca_topic_score_gemma":0.00001528843,"domain_scores_codex":[0.9976223,0.000142313,0.0006292764,0.0006398718,0.0004043956,0.000561844],"domain_scores_gemma":[0.9987993,0.0004281426,0.0001673869,0.0002813314,0.000106321,0.0002175227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006314403,0.0001119763,0.007881635,0.0007365858,0.00003067011,0.0000582354,0.0003109011,0.000004652023,0.9763049,0.000004877569,0.0003463439,0.01357782],"study_design_scores_gemma":[0.001947192,0.0001521248,0.03045451,0.0005159634,0.0000370572,0.00002455867,0.0001621386,0.001362829,0.9639593,0.00001870125,0.00114244,0.0002232067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974003,0.0007152501,0.00007831048,0.0004683114,0.00009402319,0.001103478,0.00006445889,0.0000511397,0.00002474529],"genre_scores_gemma":[0.9899603,0.009266961,0.0001523442,0.0001464784,0.00008016649,0.0001547448,0.0001097149,0.00007509645,0.00005421579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02257288,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112515694893201,"score_gpt":0.2666427429955478,"score_spread":0.2455175860466158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}