{"id":"W4313590662","doi":"10.1111/pai.13900","title":"Pathogenesis, immunology, and immune‐targeted management of the multisystem inflammatory syndrome in children (MIS‐C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper","year":2023,"lang":"en","type":"article","venue":"Pediatric Allergy and Immunology","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Hospital for Sick Children; University of Toronto","funders":"Instituto de Salud Carlos III; Hospital for Sick Children; AstraZeneca; Aimmune Therapeutics; European Academy of Allergy and Clinical Immunology; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Innovationsfonden; National Science Foundation; Danone; Canadian Institutes of Health Research; Regeneron Pharmaceuticals","keywords":"Medicine; Macrophage activation syndrome; Immunology; Cytokine storm; Clinical immunology; Immune system; Cytokine release syndrome; Vaccination; Systemic inflammatory response syndrome; Disease; Intensive care medicine; Sepsis; Allergy; Coronavirus disease 2019 (COVID-19); Immunotherapy; Infectious disease (medical specialty); Arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003039252,0.0003737568,0.0006428075,0.0005999454,0.0002681251,0.00001565846,0.0003244127,0.0003535748,0.00005777087],"category_scores_gemma":[0.00003011748,0.0002945382,0.0001498757,0.0009945962,0.0001886945,0.0001859612,0.0004139016,0.0003405965,0.00007378114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009351576,"about_ca_system_score_gemma":0.0001539541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008433407,"about_ca_topic_score_gemma":0.00001674375,"domain_scores_codex":[0.9973534,0.000315398,0.0009746887,0.0005846087,0.0002421318,0.0005297182],"domain_scores_gemma":[0.9985355,0.0001311574,0.000379497,0.0007647849,0.00009268387,0.0000963528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008827976,0.0005148228,0.9836707,0.001471359,0.001988133,0.001012795,0.0005516867,0.00004096365,0.005048356,0.001922268,0.0001031986,0.002792939],"study_design_scores_gemma":[0.003078791,0.0002718849,0.9928063,0.0001119116,0.0003643464,0.002291815,0.0005209791,0.00006105762,0.00003037175,0.00006169633,0.0001084335,0.0002923811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677215,0.03007457,0.000008688515,0.0003028701,0.0002760833,0.001330561,0.00004671073,0.0001574333,0.0000815381],"genre_scores_gemma":[0.9778569,0.0209967,0.00005552357,0.00005240598,0.0000704572,0.0003797046,0.0001275454,0.00004898323,0.0004118317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0101353,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006294007865554927,"score_gpt":0.2110651659452664,"score_spread":0.2047711580797115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}