{"id":"W4313596242","doi":"10.1002/jsp2.1240","title":"Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue","year":2023,"lang":"en","type":"article","venue":"JOR Spine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; European Commission; H2020 European Research Council; Arthritis Society; Dutch Arthritis Society","keywords":"Extracellular; Lactate dehydrogenase; Chemistry; Metabolism; Cell; Biophysics; Staining; Glycolysis; Nucleus; Extracellular matrix; Cell growth; Biochemistry; Cell biology; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032948,0.0001047024,0.0001900102,0.0001149057,0.00003951772,0.00001188477,0.0001064032,0.000107628,0.000007658739],"category_scores_gemma":[0.0001547322,0.0001101394,0.00003036243,0.0003082021,0.00003698373,0.000004855899,0.0002246334,0.000090651,0.00001842876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003244018,"about_ca_system_score_gemma":0.00004766349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001414271,"about_ca_topic_score_gemma":0.0008488024,"domain_scores_codex":[0.999072,0.00006284938,0.0001489239,0.000288328,0.0001546588,0.0002732722],"domain_scores_gemma":[0.9995588,0.000009533825,0.00005134004,0.0002219455,0.00005780534,0.000100593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119097,0.00005462004,0.002554061,0.0000543831,0.00000806039,0.00001445663,0.000009310988,0.00006088216,0.9947057,0.000004091452,0.0001050159,0.002317466],"study_design_scores_gemma":[0.0005062053,0.0001907268,0.09737018,0.00001173903,0.000008353714,0.000003195355,0.000006264468,0.003256283,0.8974969,0.000008120479,0.001045971,0.00009607417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964432,0.0001443753,0.002721542,0.0001405438,0.00005857671,0.0002514703,0.00005980681,0.00001294871,0.0001674965],"genre_scores_gemma":[0.9988571,0.0001205609,0.0004100815,0.00001378262,0.00004001645,0.00001138809,0.0001516918,0.00001367236,0.0003816376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09720885,"threshold_uncertainty_score":0.4491354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007991875216413105,"score_gpt":0.2723091231390736,"score_spread":0.2643172479226605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}