{"id":"W4313613594","doi":"10.1101/2023.01.06.522977","title":"Omicron Spike Protein Is Vulnerable to Reduction","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Toronto","funders":"","keywords":"Chemistry; Disulfide bond; Cleavage (geology); Receptor; Biophysics; Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477812,0.0002341311,0.0001962908,0.0001088508,0.000141911,0.0001958567,0.0001656272,0.0002983373,0.001137047],"category_scores_gemma":[0.0001949722,0.00008565698,0.0002533607,0.0001333516,0.0002000411,0.0001073743,0.0001845696,0.0003707915,0.0003043616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409953,"about_ca_system_score_gemma":0.0001168964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529249,"about_ca_topic_score_gemma":0.0004441468,"domain_scores_codex":[0.9998453,0.00002721688,0.00001116508,0.00002804107,0.00005347305,0.00003478858],"domain_scores_gemma":[0.9998339,0.00002928984,0.00006659471,0.00001924448,0.00002654219,0.00002428262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000812313,0.0000136164,0.00033244,0.00001394667,0.000005917217,0.00006047309,0.0000101772,0.00004594381,0.9988459,0.00004541115,0.00003356298,0.0005113429],"study_design_scores_gemma":[0.000007292099,0.0001998933,0.005882672,0.000004315649,0.000008033589,0.0005534373,0.000028989,0.0005023199,0.9916117,0.00006114031,0.001136201,0.000003980322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976675,0.0002591916,0.001118942,0.00006203762,0.00001313767,0.0000100812,0.0001670133,0.0000212064,0.0006808913],"genre_scores_gemma":[0.997961,0.00008690509,0.0007421101,0.00006922806,0.000004353658,0.000006938355,0.000384861,0.00001545279,0.0007290408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137047,"threshold_uncertainty_score":0.00380379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399352058296218,"score_gpt":0.3014659175817634,"score_spread":0.2615307117521416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}