{"id":"W4313627518","doi":"10.1016/j.clgc.2023.01.001","title":"Safety Profile of Ipatasertib Plus Abiraterone vs Placebo Plus Abiraterone in Metastatic Castration-resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Foundation Medicine; Ipsen; National Institute for Health and Care Research; Astellas Pharma; F. Hoffmann-La Roche; Sanofi; Pfizer; Genentech; Medical Research Council; PharmaMar; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Discontinuation; Placebo; Prostate cancer; Internal medicine; Prednisone; Rash; Adverse effect; Prednisolone; Gastroenterology; Cancer; Oncology; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001422926,0.0005176885,0.001726358,0.0003188879,0.0001913032,0.0006215832,0.0004207455,0.0006063721,0.002793553],"category_scores_gemma":[0.001881754,0.0002144462,0.00141811,0.000445179,0.0004183673,0.0004793365,0.0002381858,0.001580436,0.0004572658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004119225,"about_ca_system_score_gemma":0.0006659228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218082,"about_ca_topic_score_gemma":0.0009354184,"domain_scores_codex":[0.9991999,0.0004267448,0.00007597539,0.00009747603,0.0001456546,0.0000541582],"domain_scores_gemma":[0.9989772,0.0002792446,0.0004653079,0.00005306407,0.00005686606,0.0001683252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8617528,0.003686878,0.004964085,0.00190248,0.002526411,0.000159373,0.0001483606,0.001415555,0.01792248,0.0001227012,0.0008955961,0.1045033],"study_design_scores_gemma":[0.393704,0.5545902,0.03549707,0.0002994259,0.003166399,0.001051163,0.0001146234,0.001788736,0.005008116,0.0005425027,0.004178071,0.00005963642],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850096,0.01147507,0.0003696363,0.0002767947,0.0001119612,0.000522118,0.0006855507,0.00006576368,0.001483534],"genre_scores_gemma":[0.9951614,0.002641211,0.000373276,0.0002248743,0.000144425,0.0003274923,0.0004775464,0.000007781989,0.0006420499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002793553,"threshold_uncertainty_score":0.009345353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045101810834043,"score_gpt":0.4297782096430927,"score_spread":0.3252680285596884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}