{"id":"W4313627518","doi":"10.1016/j.clgc.2023.01.001","title":"Safety Profile of Ipatasertib Plus Abiraterone vs Placebo Plus Abiraterone in Metastatic Castration-resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Foundation Medicine; Ipsen; National Institute for Health and Care Research; Astellas Pharma; F. Hoffmann-La Roche; Sanofi; Pfizer; Genentech; Medical Research Council; PharmaMar; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Discontinuation; Placebo; Prostate cancer; Internal medicine; Prednisone; Rash; Adverse effect; Prednisolone; Gastroenterology; Cancer; Oncology; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001072743,0.0004160992,0.001210867,0.0003294215,0.0001368059,0.00003142301,0.0002544637,0.0001918116,0.001032211],"category_scores_gemma":[0.0001436507,0.00032681,0.000243035,0.001130792,0.0004462223,0.0002117838,0.0001956113,0.0006720566,0.0001670156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008944001,"about_ca_system_score_gemma":0.002828411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560793,"about_ca_topic_score_gemma":0.001042724,"domain_scores_codex":[0.9955262,0.0003491913,0.00164397,0.0008398377,0.0007159861,0.0009248084],"domain_scores_gemma":[0.9979223,0.0003790327,0.0003499957,0.0006144308,0.0003059015,0.000428324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3560484,0.004711553,0.3196518,0.009586946,0.00404204,0.01508687,0.006219559,0.01486649,0.1029571,0.00007684953,0.07634987,0.0904025],"study_design_scores_gemma":[0.08723307,0.008888867,0.8281426,0.003363938,0.001082335,0.0000537169,0.002053268,0.01033417,0.04012571,0.0002189702,0.01695657,0.001546724],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870995,0.003925611,0.000006065201,0.003423666,0.0007480797,0.002818991,0.001439438,0.000125619,0.0004130442],"genre_scores_gemma":[0.9697222,0.01150671,0.0003645521,0.0002892153,0.0005116776,0.001868636,0.0007644138,0.0001019207,0.01487071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5084909,"threshold_uncertainty_score":0.9999184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045101810834043,"score_gpt":0.4297782096430927,"score_spread":0.3252680285596884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}