{"id":"W4313640774","doi":"10.21203/rs.3.rs-2386414/v1","title":"NRF2 Transcriptionally Regulates Caspase-11 Expression to Activate HMGB1 Release by Hepatocytes","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Inflammasome; Autophagy; Cell biology; HMGB1; Caspase 1; Downregulation and upregulation; Biology; Chromatin immunoprecipitation; AIM2; Transcription factor; Caspase; Programmed cell death; Caspase 3; Chemistry; Apoptosis; Inflammation; Gene expression; Biochemistry; Promoter; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001574893,0.0003679937,0.0003391021,0.0005698011,0.000218506,0.0001210835,0.0009116008,0.0005642405,0.000150702],"category_scores_gemma":[0.002035078,0.0003707014,0.0001491087,0.0006474232,0.0001761259,0.00001377766,0.001467467,0.001216717,0.0001720442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288277,"about_ca_system_score_gemma":0.0006367799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000493452,"about_ca_topic_score_gemma":0.0002744184,"domain_scores_codex":[0.9947294,0.0007904775,0.0004435166,0.001631352,0.001366425,0.001038828],"domain_scores_gemma":[0.9969513,0.0001577687,0.00007939959,0.001473941,0.0008852705,0.0004523077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005836824,0.0001840341,0.002116268,0.0006001826,0.0000326239,0.00004579746,0.0001864712,0.003420033,0.9420494,0.00005415863,0.04911574,0.001611548],"study_design_scores_gemma":[0.00057438,0.0003071935,0.003834137,0.0007699032,0.000004060829,0.000004336363,0.0003089414,0.0002097995,0.9021737,0.001448622,0.08982247,0.0005424442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986455,0.002169388,0.001332314,0.005912044,0.0002381227,0.002553937,0.0009310369,0.00009724151,0.0003109157],"genre_scores_gemma":[0.974673,0.001942207,0.001736528,0.00007787269,0.0004975806,0.001274014,0.003569584,0.0001681429,0.01606103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04070673,"threshold_uncertainty_score":0.9998745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0678609160646398,"score_gpt":0.4005653328872868,"score_spread":0.332704416822647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}