{"id":"W4313640774","doi":"10.21203/rs.3.rs-2386414/v1","title":"NRF2 Transcriptionally Regulates Caspase-11 Expression to Activate HMGB1 Release by Hepatocytes","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Inflammasome; Autophagy; Cell biology; HMGB1; Caspase 1; Downregulation and upregulation; Biology; Chromatin immunoprecipitation; AIM2; Transcription factor; Caspase; Programmed cell death; Caspase 3; Chemistry; Apoptosis; Inflammation; Gene expression; Biochemistry; Promoter; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235309,0.0003581709,0.000352092,0.0002583791,0.00015945,0.0003002523,0.0001168314,0.0002364783,0.00340417],"category_scores_gemma":[0.0001190956,0.0001948052,0.0004114294,0.0001499069,0.0003181578,0.0002859994,0.0002380982,0.000597887,0.0009365162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795972,"about_ca_system_score_gemma":0.0001958365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002661217,"about_ca_topic_score_gemma":0.0004429939,"domain_scores_codex":[0.9997374,0.00004111766,0.00003116644,0.00007400403,0.00005027704,0.00006592074],"domain_scores_gemma":[0.9998649,0.00001722087,0.00003734219,0.00001967525,0.00002361478,0.00003718285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781491,0.00004389951,0.0002300484,0.00006955441,0.000005761312,0.00005268348,0.00002095696,0.00002456364,0.9985031,0.00009442849,0.00007452724,0.0006023854],"study_design_scores_gemma":[0.00004181286,0.0002337418,0.005387674,0.0000126238,0.00001691566,0.0002159695,0.00008751309,0.0007623498,0.9900839,0.00008014181,0.003070897,0.000006498464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838321,0.003594715,0.007055217,0.0004220189,0.0001541412,0.00008043106,0.001764403,0.0002508853,0.002846227],"genre_scores_gemma":[0.9911157,0.0007062385,0.002033044,0.0001474025,0.0000188176,0.00007116042,0.000951382,0.00003002511,0.004926307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00340417,"threshold_uncertainty_score":0.01138806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0678609160646398,"score_gpt":0.4005653328872868,"score_spread":0.332704416822647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}