{"id":"W4313640794","doi":"10.1038/s41380-022-01928-6","title":"Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signalling","year":2023,"lang":"en","type":"article","venue":"HAL (Le Centre pour la Communication Scientifique Directe)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"Instituto de Salud Carlos III; Novo Nordisk Fonden; Université de Bordeaux; National Institute of Mental Health; Centre National de la Recherche Scientifique; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Brain and Behavior Research Foundation; Agence Nationale de la Recherche; Ministerio de Economía y Competitividad; U.S. Department of Health and Human Services","keywords":"Dopamine receptor D2; Docosahexaenoic acid; Polyunsaturated fatty acid; Allosteric regulation; Dopamine; Chemistry; Receptor; Dopamine receptor; Pharmacology; Biochemistry; Biology; Neuroscience; Fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008821925,0.0002101671,0.0002189223,0.00005639668,0.0001775393,0.0003270307,0.0001825582,0.0002339912,0.001860656],"category_scores_gemma":[0.0001831569,0.0001077513,0.0002149324,0.00006385952,0.0002110866,0.0002767277,0.0002784042,0.0003131477,0.0003264628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004214493,"about_ca_system_score_gemma":0.0002504899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002119421,"about_ca_topic_score_gemma":0.001917477,"domain_scores_codex":[0.9999415,0.0000135363,0.000003977816,0.00001305574,0.00001047639,0.00001753877],"domain_scores_gemma":[0.9999443,0.00001822159,0.00001376131,0.000006034029,0.000006057161,0.00001165801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008479161,0.00003786061,0.001011818,0.0001087212,0.00005226213,0.0001372749,0.00002891341,0.001923452,0.9909293,0.001072091,0.00009238554,0.003758052],"study_design_scores_gemma":[0.0001190425,0.0003712758,0.01031405,0.00002882543,0.00008374573,0.0002691859,0.0001372703,0.02196772,0.960094,0.001453786,0.005120595,0.00004049571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944813,0.001480035,0.002066858,0.0001851779,0.00002525237,0.000008695573,0.0001890457,0.0000365943,0.001527029],"genre_scores_gemma":[0.9978108,0.0008615174,0.000708723,0.00005035484,0.000002833166,0.000007810039,0.00009105405,0.000009291871,0.0004575462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002119421,"threshold_uncertainty_score":0.006224513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106520492224818,"score_gpt":0.2362254820408655,"score_spread":0.2255734328183837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}