{"id":"W4313645953","doi":"10.1038/s41467-022-35778-1","title":"Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"SLAC National Accelerator Laboratory; Lawrence Berkeley National Laboratory; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Cancer Institute; Michigan State University; Pelotonia; College of Engineering, Michigan State University; D. Warren Brown Family Foundation; Eli Lilly and Company; European Hematology Association; U.S. Department of Health and Human Services; Ohio State University; American Cancer Society; Canadian Light Source","keywords":"Protein arginine methyltransferase 5; Chronic lymphocytic leukemia; Cancer research; Lymphoma; Leukemia; Biology; Methyltransferase; Tumor progression; Genetically modified mouse; Malignant transformation; Transgene; Medicine; Immunology; Gene; Genetics; Methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410733,0.000100568,0.0001331345,0.0001679921,0.00006368152,0.000005348786,0.0002922028,0.0003047147,0.000002407093],"category_scores_gemma":[0.00005198861,0.00008953206,0.00004414043,0.0006753754,0.0001125773,0.00001454182,0.00007162574,0.0002022455,0.000001599339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004939324,"about_ca_system_score_gemma":0.0006476293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009886573,"about_ca_topic_score_gemma":0.001317932,"domain_scores_codex":[0.9991469,0.0001173226,0.000306289,0.0001478653,0.000164642,0.000116945],"domain_scores_gemma":[0.9986833,0.00003278185,0.0002770141,0.0008202487,0.0001655589,0.00002113669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004139646,0.00009376391,0.01223408,0.0002539649,0.0002001806,3.112981e-7,0.001046996,0.1246091,0.811259,0.00188667,0.0003737969,0.04762817],"study_design_scores_gemma":[0.002756194,0.0006506033,0.30666,0.0004230732,0.0001229711,0.000007106878,0.0001028332,0.08037312,0.6053458,0.0003870556,0.002893587,0.0002775543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959943,0.002689998,0.0003241902,0.0001847078,0.00003762448,0.0005243923,0.00003396677,0.00002677737,0.0001840551],"genre_scores_gemma":[0.9959821,0.001332669,0.001415325,0.000003995906,0.00002738708,0.00006568523,0.001127662,0.00001652057,0.00002870835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.294426,"threshold_uncertainty_score":0.3651012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007430127109013088,"score_gpt":0.2785510037628156,"score_spread":0.2711208766538025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}