{"id":"W4313646690","doi":"10.1002/dvdy.565","title":"Dysregulation of Grainyhead‐like 3 expression causes widespread developmental defects","year":2023,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Biology; Transgene; Phenotype; Conditional gene knockout; Ectopic expression; Cell biology; Gene knockin; Knockout mouse; Loss function; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416067,0.0006217779,0.0002935082,0.000499312,0.0002007278,0.0002743503,0.0002810886,0.0004509086,0.002173756],"category_scores_gemma":[0.0001055516,0.0002056522,0.0003083475,0.0002285383,0.0004745961,0.0001537367,0.0003701028,0.0006053117,0.0005892979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590683,"about_ca_system_score_gemma":0.0002320592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004771286,"about_ca_topic_score_gemma":0.001161049,"domain_scores_codex":[0.9997775,0.00001566614,0.00002635398,0.00006579763,0.00007146851,0.00004320727],"domain_scores_gemma":[0.999774,0.00002371005,0.000117178,0.00002036568,0.000007810189,0.00005687013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005030623,0.00001495464,0.0002122729,0.00001950297,0.000004039269,0.0001415387,0.000007409576,0.00003157109,0.9988202,0.00005922612,0.00003339291,0.0006056249],"study_design_scores_gemma":[0.00003916594,0.0002695148,0.01021214,0.00001376922,0.00004613727,0.001589857,0.00004068712,0.0006241792,0.9840086,0.0000745119,0.003073587,0.00000790769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907902,0.001114191,0.005068046,0.000119174,0.00004244268,0.00004671991,0.001042,0.0004972562,0.001280001],"genre_scores_gemma":[0.991544,0.0007610312,0.002460835,0.00007174726,0.00001146356,0.00004836059,0.0008038114,0.00009507126,0.004203741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173756,"threshold_uncertainty_score":0.007271945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185184966734275,"score_gpt":0.2376922968801375,"score_spread":0.2258404472127948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}