{"id":"W4313648100","doi":"10.1002/jev2.12298","title":"Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility","year":2023,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"National Cancer Institute; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Extracellular vesicles; Biology; Phylum; Rigour; Helminths; Helminth infections; Function (biology); Schistosoma; Ecology; Computational biology; Data science; Zoology; Evolutionary biology; Computer science; Schistosoma mansoni; Cell biology; Schistosomiasis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004644001,0.0004049765,0.0008208943,0.0002771593,0.0004091373,0.00008570996,0.000467783,0.0002198396,0.0000396947],"category_scores_gemma":[0.01017609,0.0003960004,0.0004089318,0.0002982322,0.0004862048,0.00004857314,0.0002660319,0.0003668201,0.00001221312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005259129,"about_ca_system_score_gemma":0.0002719013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005648304,"about_ca_topic_score_gemma":0.0001346481,"domain_scores_codex":[0.9958954,0.0008622364,0.001581828,0.000750302,0.0004412917,0.0004689649],"domain_scores_gemma":[0.9952744,0.001085293,0.000870331,0.001541849,0.0008136631,0.0004145045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007452351,0.0005711493,0.003192973,0.0001861904,0.0005385578,0.0001282994,0.001620255,0.0003061886,0.9786007,0.0002834036,0.01107577,0.002751298],"study_design_scores_gemma":[0.002426496,0.001369504,0.01198873,0.0002747518,0.0005257485,0.0001182295,0.005737933,0.0001539749,0.9501866,0.01841197,0.00822024,0.0005858092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765163,0.01999451,0.001034154,0.000785741,0.0006296194,0.0007438798,0.0002292607,0.00002647671,0.00004004079],"genre_scores_gemma":[0.9868904,0.0005133646,0.009473638,0.0001095878,0.002344475,0.00003745942,0.00007443626,0.00007113228,0.000485471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02841406,"threshold_uncertainty_score":0.9998492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05080220238215204,"score_gpt":0.3248773512606268,"score_spread":0.2740751488784747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}