{"id":"W4313648100","doi":"10.1002/jev2.12298","title":"Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility","year":2023,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"National Cancer Institute; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Extracellular vesicles; Biology; Phylum; Rigour; Helminths; Helminth infections; Function (biology); Schistosoma; Ecology; Computational biology; Data science; Zoology; Evolutionary biology; Computer science; Schistosoma mansoni; Cell biology; Schistosomiasis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.438347,0.002802762,0.007809276,0.005779334,0.00510432,0.01818063,0.01085928,0.01015904,0.007324016],"category_scores_gemma":[0.4033601,0.002396725,0.005053722,0.004309414,0.01898427,0.01878762,0.02671735,0.01646759,0.007618535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004872259,"about_ca_system_score_gemma":0.01968771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002446369,"about_ca_topic_score_gemma":0.003154737,"domain_scores_codex":[0.6969053,0.2029129,0.03191848,0.01321256,0.05094266,0.00410816],"domain_scores_gemma":[0.4171477,0.1992804,0.01638495,0.215989,0.13846,0.01273805],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004227947,0.0007924684,0.01205874,0.02917814,0.002033836,0.002456769,0.01688976,0.003715276,0.122264,0.2374448,0.1195476,0.4493906],"study_design_scores_gemma":[0.0003729238,0.001231788,0.00585511,0.0117401,0.00063671,0.001758178,0.003703472,0.003488005,0.03684684,0.1946851,0.7391745,0.0005072898],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01381784,0.1012129,0.6760535,0.1352916,0.03643298,0.007852972,0.002681182,0.003955264,0.02270184],"genre_scores_gemma":[0.06768174,0.04263308,0.8139791,0.0283894,0.01145497,0.01810468,0.004155374,0.00293551,0.01066606],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.561653,"threshold_uncertainty_score":0.6926181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05080220238215204,"score_gpt":0.3248773512606268,"score_spread":0.2740751488784747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}