{"id":"W4313650407","doi":"10.1101/2023.01.03.522662","title":"Artificial nanovesicles for dsRNA delivery in spray induced gene silencing for crop protection","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Framework Programme; European Commission; Ministerio de Ciencia e Innovación; Canadian Institute for Advanced Research; National Science Foundation","keywords":"RNA silencing; RNA interference; Gene silencing; Biology; Crop protection; Nanocarriers; RNA; Gene; Biochemistry; Pharmacology; Agronomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152272,0.0004030389,0.0005082635,0.000124268,0.000419136,0.0002285761,0.0004828753,0.0004707547,0.00000723627],"category_scores_gemma":[0.0009168825,0.0002212217,0.0001994821,0.000610828,0.00006514305,0.0001432347,0.0004180012,0.0004573787,0.0000252064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786025,"about_ca_system_score_gemma":0.0001556107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006778378,"about_ca_topic_score_gemma":0.0005574499,"domain_scores_codex":[0.9972066,0.0001137407,0.0005414538,0.000992245,0.0003556503,0.0007903554],"domain_scores_gemma":[0.99853,0.0004168731,0.0002850019,0.0001857618,0.0004428318,0.0001394824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000150322,0.00008490451,0.0002322893,0.0001758183,0.00005691786,0.000009074925,0.000007942807,0.00003553598,0.9989024,0.00003368027,0.0001819426,0.0001291964],"study_design_scores_gemma":[0.0001746344,0.0001655667,0.05817419,0.0002489944,0.00002389351,5.661551e-9,0.00001220813,0.0004980338,0.9393342,0.00002669639,0.0008546846,0.0004868624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927909,0.0002083837,0.0001165643,0.0005859614,0.0007169489,0.002970116,0.002302383,0.0003083586,4.212146e-7],"genre_scores_gemma":[0.9954467,0.000143051,0.0007714114,0.0000509872,0.001069721,0.002495119,0.000003342101,0.00001405998,0.000005600794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05956814,"threshold_uncertainty_score":0.9021158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09464749926107414,"score_gpt":0.2616473116918584,"score_spread":0.1669998124307843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}