{"id":"W4313654904","doi":"10.1016/j.biopha.2022.114167","title":"Distinct effects of α-linolenic acid and docosahexaenoic acid on the expression of genes related to cholesterol metabolism and the response to infection in THP-1 monocytes and immune cells of obese humans","year":2023,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Research Manitoba","keywords":"Docosahexaenoic acid; Immune system; Biology; Transcriptome; Monocyte; Immunology; Peripheral blood mononuclear cell; Inflammation; Fatty acid desaturase; Lipid metabolism; Gene expression; Polyunsaturated fatty acid; Fatty acid; Biochemistry; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001836503,0.0001796933,0.0004537624,0.0005538773,0.0001130805,0.00001196897,0.000143719,0.00006763491,0.00001161128],"category_scores_gemma":[0.0001559112,0.0000979061,0.00004357695,0.0008093562,0.0003709351,0.00006139511,0.00007363903,0.0002129709,0.000001938195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002309542,"about_ca_system_score_gemma":0.00002136193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463153,"about_ca_topic_score_gemma":0.00003158385,"domain_scores_codex":[0.997861,0.000843075,0.0004558946,0.0002555406,0.0003112262,0.0002733205],"domain_scores_gemma":[0.9983783,0.00101141,0.0001614232,0.0002665753,0.00005614487,0.000126134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01110743,0.0001049483,0.002197232,0.000344723,0.0000324899,0.000002067837,0.00648652,0.000005101438,0.959246,0.00001101786,0.0001362159,0.02032623],"study_design_scores_gemma":[0.005794538,0.001167198,0.2187803,0.0005742845,0.00002461363,0.000001563852,0.0001005649,0.00009257517,0.7729681,0.00006718362,0.0003628801,0.00006618306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834781,0.009499483,0.00002067753,0.005148585,0.0002359047,0.001572744,0.000014444,0.00002451391,0.000005565286],"genre_scores_gemma":[0.9921477,0.007331768,0.00003412369,0.0003086941,0.00004840575,0.00008326136,0.000003074198,0.00002416912,0.00001884871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.216583,"threshold_uncertainty_score":0.3992495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803975311150474,"score_gpt":0.338866883542616,"score_spread":0.3208271304311113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}