{"id":"W4313678704","doi":"10.1002/jat.4434","title":"Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies","year":2023,"lang":"en","type":"article","venue":"Journal of Applied Toxicology","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cantox Health Sciences International; Intertek (Canada)","funders":"","keywords":"Curcumin; Genotoxicity; Curcuminoid; Micronucleus test; Bioavailability; Ames test; Chemistry; Micronucleus; Pharmacology; In vivo; Toxicity; Salmonella; Biology; Biochemistry; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000650309,0.0005839802,0.0004155544,0.0004429722,0.000278581,0.000214563,0.0003028489,0.0005935175,0.001585069],"category_scores_gemma":[0.0005991671,0.0001799046,0.0003735986,0.0002404422,0.0002716447,0.0002092234,0.0002393274,0.0003773435,0.0004539144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554676,"about_ca_system_score_gemma":0.0003676989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008572621,"about_ca_topic_score_gemma":0.001131007,"domain_scores_codex":[0.9996883,0.00007863677,0.00002521357,0.00007925413,0.0001023539,0.0000262787],"domain_scores_gemma":[0.9994898,0.0001163442,0.0001394896,0.00006115726,0.0001482258,0.00004499754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006902218,0.0004086258,0.0004097238,0.0002057533,0.00002504383,0.0001201193,0.00008185495,0.0005044236,0.9929495,0.00005333204,0.0001187702,0.004432607],"study_design_scores_gemma":[0.000111621,0.01702189,0.003290271,0.00003791882,0.0001263468,0.0003111922,0.00007466483,0.001126571,0.9727004,0.0000641721,0.005116091,0.00001878249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780313,0.0019881,0.01647057,0.0001164293,0.00006529996,0.0008554026,0.0007476086,0.0001354183,0.001589881],"genre_scores_gemma":[0.9754747,0.003157092,0.01453832,0.0001564562,0.000038941,0.0008676844,0.001122727,0.00006861527,0.00457549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585069,"threshold_uncertainty_score":0.005302548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973830596679041,"score_gpt":0.3521743367375966,"score_spread":0.3324360307708062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}