{"id":"W4313679928","doi":"10.1038/s41388-022-02573-7","title":"Chaperone-mediated autophagy promotes PCa survival during ARPI through selective proteome remodeling","year":2023,"lang":"en","type":"article","venue":"Oncogene","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Terry Fox Foundation","keywords":"Biology; Autophagy; Cell biology; Enzalutamide; Unfolded protein response; Androgen receptor; Downregulation and upregulation; Transcriptome; Proteome; Integrated stress response; Signal transduction; Cancer research; Cell growth; Proteostasis; Cellular stress response; mTORC1; Protein degradation; Prostate cancer; PI3K/AKT/mTOR pathway; Apoptosis; Biochemistry; Gene expression; Cancer; Gene; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129953,0.0002389332,0.0003096393,0.0002932892,0.0005340358,0.0008029378,0.0001746093,0.0002732093,0.002904388],"category_scores_gemma":[0.0001271045,0.0001264926,0.0004405246,0.0002704539,0.0002525994,0.0003568197,0.0003114927,0.0009506444,0.0009914638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004619261,"about_ca_system_score_gemma":0.0004895927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000964684,"about_ca_topic_score_gemma":0.002369094,"domain_scores_codex":[0.9998561,0.00001085742,0.000005881429,0.00002264447,0.00003127704,0.00007332074],"domain_scores_gemma":[0.9999115,0.000005926853,0.00001856222,0.00001254956,0.00001737592,0.00003395019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006369447,0.0001245949,0.00100295,0.0001142324,0.00002396137,0.0003240353,0.00004433451,0.000133425,0.9886357,0.001060826,0.001602756,0.006296333],"study_design_scores_gemma":[0.00005010412,0.000367237,0.03035844,0.00002082131,0.0000541357,0.001170128,0.0001919658,0.002054783,0.9488545,0.0004612936,0.01639667,0.00001998821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778233,0.004221324,0.005614568,0.0006886826,0.0002062036,0.00007283028,0.001412638,0.0006338726,0.009326619],"genre_scores_gemma":[0.9942235,0.0007188718,0.0008383446,0.00008820755,0.00002590136,0.00003631503,0.0005268664,0.00003811311,0.003503722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904388,"threshold_uncertainty_score":0.009716153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378221910947778,"score_gpt":0.3080400134446835,"score_spread":0.2742577943352058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}