{"id":"W4313680950","doi":"10.1016/j.ajog.2023.01.007","title":"Cytogenetic outcomes following a failed cell-free DNA screen: a population-based retrospective cohort study of 35,146 singleton pregnancies","year":2023,"lang":"en","type":"article","venue":"American Journal of Obstetrics and Gynecology","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Ottawa; Sunnybrook Health Science Centre; North York General Hospital; University of Toronto; Newborn Screening Ontario; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"Canadian Institutes of Health Research; Children's Hospital of Eastern Ontario Foundation","keywords":"Cell-free fetal DNA; Medicine; Obstetrics; Aneuploidy; Population; Cohort; Retrospective cohort study; Poisson regression; Cohort study; Pregnancy; Gestational age; Trisomy; Chromosome; Prenatal diagnosis; Genetics; Fetus; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001128673,0.0003356686,0.0005561424,0.0009848801,0.0009878823,0.0008124255,0.0008662319,0.0005172562,0.001105675],"category_scores_gemma":[0.003801555,0.0007860351,0.000663678,0.001627052,0.0005685285,0.0004716527,0.000930946,0.0004965849,0.000194088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002338237,"about_ca_system_score_gemma":0.002071106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1680058,"about_ca_topic_score_gemma":0.1921951,"domain_scores_codex":[0.9988512,0.0001409323,0.000156132,0.0003487051,0.0002620424,0.0002410499],"domain_scores_gemma":[0.9980433,0.0002834756,0.0008628883,0.0002486536,0.0002483578,0.0003132873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003452695,0.00001495532,0.9991602,0.000009752584,0.0000326178,0.0001151749,0.0001678256,0.00001740924,0.00007578856,0.00001036258,0.00004348682,0.0003179779],"study_design_scores_gemma":[0.000007262882,0.00006307338,0.9990939,0.00001018522,0.00003221095,0.0002400791,0.000329802,0.00007156405,0.00002427335,0.00001117574,0.0001119553,0.000004636088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987034,0.0001707812,0.00008264583,0.00001870902,0.000003007559,0.00002966594,0.000805704,0.000002645219,0.000183455],"genre_scores_gemma":[0.9990287,0.0001624078,0.00008603601,0.00002650385,0.000003526329,0.00003012241,0.0005581976,0.000001935175,0.0001027165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1680058,"threshold_uncertainty_score":0.3340558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302188701766737,"score_gpt":0.2654477690186249,"score_spread":0.2524258820009576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}