{"id":"W4313681097","doi":"10.1016/j.gene.2023.147179","title":"Breast cancer sub-types display heterogeneity in gene amplification and mRNA expression of the anti-apoptotic members of BCL2 family","year":2023,"lang":"en","type":"article","venue":"Gene","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"MCL1; Breast cancer; Biology; Gene duplication; Cancer; Apoptosis; Cancer research; Gene; Messenger RNA; Basal (medicine); Genetics; Downregulation and upregulation; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268361,0.0001931649,0.0003571718,0.001257011,0.0001975454,0.0005626238,0.0002285893,0.0002585923,0.001656433],"category_scores_gemma":[0.0006317171,0.0001055719,0.0002842997,0.001566187,0.0001650612,0.0002267048,0.000396697,0.0002472845,0.000550588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177632,"about_ca_system_score_gemma":0.0001295459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007380588,"about_ca_topic_score_gemma":0.0009006809,"domain_scores_codex":[0.9996235,0.00003067847,0.00004789563,0.0001001627,0.0001297817,0.00006797162],"domain_scores_gemma":[0.9993777,0.000135461,0.0002998611,0.0000567114,0.00007757083,0.00005282722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001774342,0.0001234823,0.6520469,0.0006471733,0.0004597405,0.002296154,0.0004527763,0.000468942,0.289866,0.0005295349,0.001656802,0.04967821],"study_design_scores_gemma":[0.00002270287,0.0001532217,0.9395876,0.0000391966,0.0002722961,0.01244119,0.000490556,0.0003617245,0.03621071,0.0008712828,0.009532504,0.00001696444],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888531,0.003826667,0.0009697172,0.00008021136,0.000009515851,0.00002327442,0.004837411,0.00007533342,0.001324774],"genre_scores_gemma":[0.9896113,0.001249603,0.0007233983,0.00006572093,0.000009691194,0.00003905402,0.007660202,0.00001820877,0.0006229235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656433,"threshold_uncertainty_score":0.005541325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110881383899832,"score_gpt":0.2468156247515792,"score_spread":0.235727486361596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}